Details:

Alternative Title:
Pediatr Infect Dis J
Personal Author:
Stockmann, Chris ; Ampofo, Krow ; Hersh, Adam L. ; Carleton, Scott T. ; Korgenski, Kent ; ... More +
Stockmann, Chris ; Ampofo, Krow ; Hersh, Adam L. ; Carleton, Scott T. ; Korgenski, Kent ; Sheng, Xiaoming ; Pavia, Andrew T. ; Byington, Carrie L. ; Less -
Description:
Background Acute otitis media (AOM) occurs as a complication of viral upper respiratory tract infections in young children. AOM and respiratory viruses both display seasonal variation. Our objective was to examine the temporal association between circulating respiratory viruses and the occurrence of pediatric ambulatory care visits for AOM. Methods This retrospective study included 9 seasons of respiratory viral activity (2002-2010) in Utah. We used Intermountain Healthcare's electronic medical records to assess community respiratory viral activity via laboratory-based active surveillance and to identify children <18 years with outpatient visits and ICD-9 codes for AOM. We assessed the strength of the association between AOM and individual respiratory viruses using interrupted time series analyses. Results During the study period, 96,418 respiratory viral tests were performed; 46,460 (48%) were positive. The most commonly identified viruses were: RSV (22%), rhinovirus (8%), influenza (8%), parainfluenza (4%), human metapneumovirus (3%), and adenovirus (3%). AOM was diagnosed during 271,268 ambulatory visits. There were significant associations between peak activity of RSV, human metapneumovirus, influenza A, and office visits for AOM. Adenovirus, parainfluenza, and rhinovirus were not associated with visits for AOM. Conclusions Seasonal RSV, human metapneumovirus, and influenza activity were temporally associated with increased diagnoses of AOM among children. These findings support the role of individual respiratory viruses in the development AOM. These data also underscore the potential for respiratory viral vaccines to reduce the burden of AOM.
Subject:
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Adolescent
Article
Child
Child, Preschool
Female
Human Metapneumovirus
Humans
Infant
Infant, Newborn
Influenza
Influenza, Human
Male
Metapneumovirus
Orthomyxoviridae
Otitis Media
Outpatients
Paramyxoviridae Infections
Pediatrics
Respiratory Syncytial Viruses
Respiratory Syncytial Virus Infections
Respiratory Tract Infection
Respiratory Tract Infections
Retrospective Studies
RSV
Seasons
Time Factors
Utah

Source:
Pediatr Infect Dis J. 32(4):314-319 ;
Pubmed ID:
23249910
Pubmed Central ID:
PMC3618601
Document Type:
Journal Article ;
Funding:
U01A1082482/PHS HHS/United States ; UL1 RR025764/RR/NCRR NIH HHS/United States ; UL1RR025764/RR/NCRR NIH HHS/United States ; U18-IP000303-01/IP/NCIRD CDC HHS/United States ; U01 AI074419/AI/NIAID NIH HHS/United States ; ... More +
U01A1082482/PHS HHS/United States ; UL1 RR025764/RR/NCRR NIH HHS/United States ; UL1RR025764/RR/NCRR NIH HHS/United States ; U18-IP000303-01/IP/NCIRD CDC HHS/United States ; U01 AI074419/AI/NIAID NIH HHS/United States ; KM1 CA156723/CA/NCI NIH HHS/United States ; U01 AI082184/AI/NIAID NIH HHS/United States ; U01AI074419-01/AI/NIAID NIH HHS/United States ; U18 IP000303/IP/NCIRD CDC HHS/United States ; U01AI082184-01/AI/NIAID NIH HHS/United States ; UL1 TR001067/TR/NCATS NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c07fd2b51f6a98d82496daa6c82452f03e7504f71fe02c4b1a76d3fd8a632b50
File Type:

Supporting Files

• 	NIHMS427675-supplement-1.eps	ps
  	NIHMS427675-supplement-2.eps	ps
  	NIHMS427675-supplement-3.docx	docx
  	nihms427675.nxml	xml
  	nihms427675f1.gif	gif
  	nihms427675f1.jpg	jpeg

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