Details:

Alternative Title:
J Clin Virol
Personal Author:
Groome, Michelle J. ; Moyes, Jocelyn ; Cohen, Cheryl ; Walaza, Sibongile ; Tempia, Stefano ; ... More +
Groome, Michelle J. ; Moyes, Jocelyn ; Cohen, Cheryl ; Walaza, Sibongile ; Tempia, Stefano ; Pretorius, Marthi ; Hellferscee, Orienka ; Chhagan, Meera ; Haffejee, Sumayya ; Dawood, Halima ; Kahn, Kathleen ; Variava, Ebrahim ; Cohen, Adam L ; von Gottberg, Anne ; Wolter, Nicole ; Venter, Marietjie ; Madhi, Shabir A. Less -
Corporate Authors:
for the South African Severe Acute Respiratory Illness (SARI) Surveillance Group
Description:
Background:

Data on human metapneumovirus (HMPV)-associated severe acute respiratory illness (SARI) are limited in settings with high human immunodeficiency virus (HIV) infection prevalence.

Objectives:

To describe clinical characteristics and seasonality (all sites), and incidence (Soweto only) of HMPV-associated SARI among children and adults.

Study design:

Active, prospective, hospital-based, sentinel surveillance for patients hospitalised with SARI was conducted at four sites in South Africa from February 2009–December 2013. Upper respiratory tract samples were tested by multiplex real-time polymerase chain reaction assays for HMPV and other respiratory viruses. Incidence of hospitalisation, stratified by age and HIV-infection status, was calculated for one hospital with population denominators.

Results:

HMPV was identified in 4.1% of patients enrolled, including 5.6% (593/10503) in children and 1.7% in adults (≥18 years; 119/6934). The majority of adults (84.0%) had an underlying medical condition, including HIV infection in 87/110 (79.1%). HMPV detection occurred perennially with periods of increased detection, which varied from year to year. The incidence of HMPV-associated hospitalisation in Soweto was highest in infants (653.3 per 100,000 person years; 95% confidence interval (CI) 602.2–707.6). The incidence was higher in HIV-infected persons compared to HIV-uninfected persons in age-groups 5–17 years (RR 6.0; 1.1–20.4), 18−44 years (RR 67.6; 38.0–132.6) and 45–64 years (RR 5.3; 3.4–8.3), while not differing in other age-groups.

Conclusions:

The burden of HMPV-associated SARI hospitalisation among adults occurred predominantly in HIV-infected persons. Among children, infants were at highest risk, with similar burden of hospitalisation in HIV-infected and HIV-uninfected children.


Subjects:
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Adolescent Adult Child Child, Preschool Coinfection HIV Infections Hospitalization Humans Incidence Infant Metapneumovirus Middle Aged Pneumovirus Infections Prospective Studies Respiratory Tract Infections Sentinel Surveillance Young Adult
Source:
J Clin Virol. 69:125-132
Pubmed ID:
26209394
Pubmed Central ID:
PMC9134797
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHSUnited States/
Place as Subject:
South Africa
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:decc84fbaa1a5228510e4230d06a61e7ae6b43c851b16358887d6b000703c5e8
Download URL:
https://stacks.cdc.gov/view/cdc/119196/cdc_119196_DS1.pdf
File Type:

Supporting Files

• 	NIHMS1796154-supplement-Supplementary_material_2.docx	docx
  	NIHMS1796154-supplement-Supplementary_material_3.docx	docx
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  	NIHMS1796154-supplement-Supplementary_material_1.docx	docx

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