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Human metapneumovirus-associated severe acute respiratory illness hospitalisation in HIV-infected and HIV-uninfected South African children and adults
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8 2015
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Source: J Clin Virol. 69:125-132
[PDF-827.23 KB]
Details:
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Alternative Title:J Clin Virol
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Personal Author:
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Description:Background:
Data on human metapneumovirus (HMPV)-associated severe acute respiratory illness (SARI) are limited in settings with high human immunodeficiency virus (HIV) infection prevalence.
Objectives:
To describe clinical characteristics and seasonality (all sites), and incidence (Soweto only) of HMPV-associated SARI among children and adults.
Study design:
Active, prospective, hospital-based, sentinel surveillance for patients hospitalised with SARI was conducted at four sites in South Africa from February 2009–December 2013. Upper respiratory tract samples were tested by multiplex real-time polymerase chain reaction assays for HMPV and other respiratory viruses. Incidence of hospitalisation, stratified by age and HIV-infection status, was calculated for one hospital with population denominators.
Results:
HMPV was identified in 4.1% of patients enrolled, including 5.6% (593/10503) in children and 1.7% in adults (≥18 years; 119/6934). The majority of adults (84.0%) had an underlying medical condition, including HIV infection in 87/110 (79.1%). HMPV detection occurred perennially with periods of increased detection, which varied from year to year. The incidence of HMPV-associated hospitalisation in Soweto was highest in infants (653.3 per 100,000 person years; 95% confidence interval (CI) 602.2–707.6). The incidence was higher in HIV-infected persons compared to HIV-uninfected persons in age-groups 5–17 years (RR 6.0; 1.1–20.4), 18−44 years (RR 67.6; 38.0–132.6) and 45–64 years (RR 5.3; 3.4–8.3), while not differing in other age-groups.
Conclusions:
The burden of HMPV-associated SARI hospitalisation among adults occurred predominantly in HIV-infected persons. Among children, infants were at highest risk, with similar burden of hospitalisation in HIV-infected and HIV-uninfected children.
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Pubmed ID:26209394
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Pubmed Central ID:PMC9134797
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Volume:69
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