Racial disparities in advanced stage colorectal cancer survival

Details

• Alternative Title:
  Cancer Causes Control
• Personal Author:
  Wallace, Kristin ; Hill, Elizabeth G. ; Lewin, David N. ; Williamson, Grace ; Oppenheimer, Stephanie ; Ford, Marvella E. ; Wargovich, Michael J. ; Berger, Franklin G. ; Bolick, Susan W. ; Thomas, Melanie B. ; Alberg, Anthony J.
• Description:
  Purpose
  
  African Americans (AA) have a higher incidence and lower survival from colorectal cancer (CRC) compared to European Americans (EA). In the present study, statewide, population-based data from South Carolina Central Cancer Registry (SCCCR) is used to investigate the relationship between race and age on advanced stage CRC survival.
  
  Methods
  
  The study population was comprised of 3865 advanced pathologically documented colon and rectal adenocarcinoma cases diagnosed between 01 January 1996 and 31 December 2006: 2673 (69%) EA and 1192 (31%) AA. Kaplan-Meier methods were used to generate median survival time and corresponding 95% confidence intervals (CI) by race, age, and gender. Factors associated with survival were evaluated by fitting Cox proportional hazards (CPH) regression models to generate Hazard Ratios (HR) and 95% CI.
  
  Results
  
  We observed a significant interaction between race and age on CRC survival (p = 0.04). Among younger patients (< 50 years), AA race was associated with a 1.34 (95% CI 1.06-1.71) higher risk of death compared to EA. Among older patients, we observed a modest increase risk of death among AA men compared to EA (HR 1.16 (95% CI 1.01-1.32) but no difference by race among women (HR 0.94 (95% CI 0.82-1.08)). Moreover, we observed that the disparity in survival has worsened over the past 15 years.
  
  Conclusions
  
  Future studies that integrate clinical, molecular, and treatment-related data are needed for advancing understanding of the racial disparity in CRC survival, especially for those < 50 years old.
  
  
• Subjects:
  Age Factors Black Or African American Colorectal Neoplasms Female Health Status Disparities Humans Incidence Middle Aged Prognosis Registries Survival Analysis White People

  More +
• Source:
  Cancer Causes Control. 24(3):463-471.
• Pubmed ID:
  23296454
• Pubmed Central ID:
  PMC3574218
• Document Type:
  Journal Article
• Funding:
  DP12-1205/DP/NCCDPHP CDC HHS/United States ; K07 CA151864/CA/NCI NIH HHS/United States ; K07CA151864-01A1/CA/NCI NIH HHS/United States ; P20 CA157071/CA/NCI NIH HHS/United States ; P30 CA138313/CA/NCI NIH HHS/United States
• Place as Subject:
  South Carolina
• Volume:
  24
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ece4a3d379a0c362f7b04905ffe38af32b401f6ce66700d266db558aff4f84d8
• Download URL:
  https://stacks.cdc.gov/view/cdc/29622/cdc_29622_DS1.pdf
• File Type:
  [PDF - 235.29 KB ]