Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs

de Wit, Emmie; Marzi, Andrea; Bushmaker, Trenton; Brining, Doug; Scott, Dana; Richt, Juergen A.; Geisbert, Thomas W.; Feldmann, Heinz

doi:10.3201/eid2104.142012

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Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs

Apr 2015
By de Wit, Emmie ; Marzi, Andrea ; Bushmaker, Trenton ; ...
http://dx.doi.org/10.3201/eid2104.142012
Source: Emerg Infect Dis. 21(4):702-704.

[PDF-562.49 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

de Wit, Emmie ; Marzi, Andrea ; Bushmaker, Trenton ; Brining, Doug ; Scott, Dana ; ... More +

de Wit, Emmie ; Marzi, Andrea ; Bushmaker, Trenton ; Brining, Doug ; Scott, Dana ; Richt, Juergen A. ; Geisbert, Thomas W. ; Feldmann, Heinz Less -
Description:

The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.
Subjects:

[+]

Animals Antibodies, Viral DNA, Recombinant Ebolavirus Genetic Vectors Immunization Immunoglobulin G Swine Vesicular Stomatitis Indiana Virus Viral Vaccines Virus Replication Virus Shedding
Source:

Emerg Infect Dis. 21(4):702-704.
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:7ca4f39df88ae9553a7d62771c40de5719c469cbd59d2deb67f32d44c9163067
Download URL:

https://stacks.cdc.gov/view/cdc/29339/cdc_29339_DS1.pdf
File Type:

	14-2012.nxml	txt
	license.txt	txt

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