Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs

de Wit, Emmie; Marzi, Andrea; Bushmaker, Trenton; Brining, Doug; Scott, Dana; Richt, Juergen A.; Geisbert, Thomas W.; Feldmann, Heinz

doi:10.3201/eid2104.142012

i

Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs

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Apr 2015
By de Wit, Emmie ; Marzi, Andrea ; Bushmaker, Trenton ; ...

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English

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Alternative Title:

Emerg Infect Dis
Personal Author:

de Wit, Emmie ; Marzi, Andrea ; Bushmaker, Trenton ; Brining, Doug ; Scott, Dana ; Richt, Juergen A. ; Geisbert, Thomas W. ; Feldmann, Heinz
Description:

The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.
Subjects:

Animals Antibodies, Viral DNA, Recombinant Ebolavirus Genetic Vectors Immunization Immunoglobulin G Swine Vesicular Stomatitis Indiana Virus Viral Vaccines Virus Replication Virus Shedding
Source:

Emerg Infect Dis. 21(4):702-704.
Document Type:

Journal Article
Volume:

21
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:7ca4f39df88ae9553a7d62771c40de5719c469cbd59d2deb67f32d44c9163067
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https://stacks.cdc.gov/view/cdc/29339/cdc_29339_DS1.pdf
File Type:

[PDF - 562.49 KB ]

14-2012.nxml

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