Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses

Marzi, Andrea; Feldmann, Friederike; Geisbert, Thomas W.; Feldmann, Heinz; Safronetz, David

doi:10.3201/eid2102.141649

i

Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses

Supporting Files Public Domain

Feb 2015
By Marzi, Andrea ; Feldmann, Friederike ; Geisbert, Thomas W. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Marzi, Andrea ; Feldmann, Friederike ; Geisbert, Thomas W. ; Feldmann, Heinz ; Safronetz, David
Description:

We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)-based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.
Subjects:

Animals Disease Models, Animal Ebolavirus Genetic Vectors Hemorrhagic Fever, Ebola Humans Lassa Fever Lassa Virus Macaca Fascicularis Vaccination Vaccines, Synthetic Vesicular Stomatitis Indiana Virus Viral Vaccines
Source:

Emerg Infect Dis. 21(2):305-307.
Document Type:

Journal Article
Place as Subject:

Africa, Western
Volume:

21
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:676a87036e9702222bfee0b2d579c947ffd8078af0a4ae78233bcd06abe246e9
Download URL:

https://stacks.cdc.gov/view/cdc/27450/cdc_27450_DS1.pdf
File Type:

[PDF - 315.95 KB ]

File Language:

English

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