Vesicular Stomatitis Virus–Based Vaccines Against Lassa and Ebola Viruses

Details

• Journal Article:
  Emerging Infectious Diseases
• Personal Author:
  Marzi, Andrea ; Feldmann, Friederike ; Geisbert, Thomas W. ; Feldmann, Heinz ; Safronetz, David
• Description:
  We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)-based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.
• Subjects:
  Animals Disease Models, Animal Ebolavirus Genetic Vectors Hantavirus Infections Hemorrhagic Fever, Ebola Humans Lassa Fever Lassa Virus Macaca Fascicularis Orthohantavirus Vaccination Vaccines, Synthetic Vesicular Stomatitis Indiana Virus Viral Vaccines Zoonoses

  More +
• Series:
  Emerging Infectious Diseases
• DOI:
  http://dx.doi.org/10.3201/eid2102.141649
• ISSN:
  1080-6059 (digital) ; 1080-6040 (print)
• Publisher:
  Centers for Disease Control and Prevention (CDC) (U.S.)
• Pubmed ID:
  25625358
• Document Type:
  Text ; Journal Article
• Genre:
  Journal Article
• Place as Subject:
  Africa, Western
• Rights:
  Public Domain
• Topic:
  Diseases & Conditions
• Location:
  Africa
• Volume:
  21
• Issue:
  2
• Citation:
  Emerg Infect Dis. 21(2):305-307.
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:23c1eca2e8c2e8f10b89f2b9c9c65c1037cb7a534bdbbc78420ff6729ec809b9a303a226aef573c9ce1c109fafcfab879187bef0caa04568f4df8eac91560cee
• Download URL:
  https://stacks.cdc.gov/view/cdc/27450/cdc_27450_DS1.pdf
• File Type:
  [PDF - 315.95 KB ]