Acetabular Dysplasia and the Risk of Developing Hip Osteoarthritis Within 4-8 Years: an Individual Participant Data Meta-analysis of 18,807 Hips From the World COACH Consortium.

Details

• Alternative Title:
  Osteoarthritis and Cartilage, 2025, v. 33, no. 3: Acetabular Dysplasia and the Risk of Developing Hip Osteoarthritis Within 4-8 Years: an Individual Participant Data Meta-analysis of 18,807 Hips From the World COACH Consortium.
• Journal Article:
  Osteoarthritis and Cartilage
• Personal Author:
  Riedstra, Noortje S. ; Boel, Fleur ; van Buuren, Michiel M.A. ; Ahedi, Harbeer ; Arbabi, Vahid ; Arden, Nigel ; Baart, Sara J. ; Bierma-Zeinstra, Sita M.A. ; Cicuttini, Flavia M. ; Cootes, Timothy F. ; Crossley, Kay M. ; Felson, David T. ; Giellis, Willem Paul ; Heerey, Joshua ; Jones, Graeme ; Kluzek, Stefan ; Lane, Nancy E. ; Lindner, Claudia ; Lynch, John A. ; van Meurs, Joyce B.J. ; Mosler, Andrea ; Nelson, Amanda E. ; Nevitt, Michael C. ; Oei, Edwin H. ; Runhaar, Jos ; Tang, Jinchi ; Weinans, Harrie ; Agricola, Rintje
• Description:
  To study the association between various radiographic definitions of acetabular dysplasia (AD) and incident radiographic hip osteoarthritis (RHOA), and to analyze in subgroups.
  
  Hips free of RHOA at baseline and with follow-up within 4-8 years were drawn from the World COACH consortium. The Wiberg center edge angle (WCEA), acetabular depth width ratio (ADR), and the modified acetabular index (mAI) were calculated. AD was defined as WCEA≤25°, and for secondary analyses as WCEA≤20°, ADR ≤250, mAI ≥ 13°, and a combination. A logistic regression model with generalized mixed effects with 3 levels adjusted for age, biological sex, and body mass index (BMI) was used. Descriptive statistics stratified by age, biological sex and BMI were reported.
  
  A total of 18,807 hips from 9 studies were included. Baseline characteristics: age 61.84 (± 8.32) years, BMI 27.40 (± 4.49) kg/m², 70.1% women. 4766 hips (25.3%) had WCEA≤25°. Within 4-8 years (mean 5.8 ±1.6) follow-up, 378 hips (2.0%) developed incident RHOA. We found an association between AD and RHOA (adjusted OR aOR 1.80 95% confidence interval CI 1.40-2.34). In secondary analyses, all other definitions of AD were also associated with incident RHOA (aOR ranging from 1.52 95% CI 1.19-1.94 to 1.96 95% CI 1.26-3.02). Descriptive statistics showed that the relative risk (RR) in AD hips to develop RHOA was higher compared to non-AD hips in age group 61-70 (RR 1.70), BMI<25 (RR 1.66), and in female hips (RR 1.73).
  
  AD was consistently associated with incident RHOA. Explorative analyses show that AD hips in women and age group 61-70 years seem to be more at risk of developing RHOA compared to non-AD hips.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Osteoarthritis, Hip
  • Female
  • Middle Aged
  • Male
  • Acetabulum
  • Aged
  • Radiography
  • Risk Factors
  • Developmental Dysplasia of the Hip
• Keywords:
  • Hip imaging
  • Risk factor
  • Developmental dysplasia
  • Harmonized
  • Epidemiology
• Source:
  Osteoarthritis and Cartilage, 2025, v. 33, no. 3
• DOI:
  https://doi.org/10.1016/j.joca.2024.12.001
• ISSN:
  1063-4584 ; 1522-9653
• Pubmed ID:
  39657871
• Pubmed Central ID:
  PMC12239852
• Document Type:
  Text
• Funding:
  P60 AR049465/AR/NIAMS NIH HHSUnited States/ ; U01 DP006266/DP/NCCDPHP CDC HHSUnited States/ ; P60 AR030701/AR/NIAMS NIH HHSUnited States/ ; R01 AR035583/AR/NIAMS NIH HHSUnited States/ ; R01 AR035584/AR/NIAMS NIH HHSUnited States/ ; U01 AG018947/AG/NIA NIH HHSUnited States/ ; R01 AG027576/AG/NIA NIH HHSUnited States/ ; R01 AG005407/AG/NIA NIH HHSUnited States/ ; P60 AR064166/AR/NIAMS NIH HHSUnited States/ ; U01 AG018832/AG/NIA NIH HHSUnited States/ ; P30 AR072571/AR/NIAMS NIH HHSUnited States/ ; R01 AR035582/AR/NIAMS NIH HHSUnited States/ ; R01 AG005394/AG/NIA NIH HHSUnited States/ ; 223267/WT_/Wellcome TrustUnited Kingdom/ ; R01 AG027574/AG/NIA NIH HHSUnited States/ ; P30 AR072580/AR/NIAMS NIH HHSUnited States/ ; U01 AG019069/AG/NIA NIH HHSUnited States/ ; U01 AG018820/AG/NIA NIH HHSUnited States/ ; U19 AG076471/AG/NIA NIH HHSUnited States/ ; U01 DP003206/DP/NCCDPHP CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  373-382 (21 pdf pages)
• Volume:
  33
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/261864/cdc_261864_DS1.pdf
• File Type:
  [PDF - 816.63 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:2df8e93e7c074e056fd5382a8b481ab2913e1abcf1c6c85d84acb0825431a6eecc7f4ddd258d34ae1a4760f931305d7367a6b1a28e89099a773bf970dc03881c