Details:

Alternative Title:
Arthritis Care Res (Hoboken)
Personal Author:
Nelson, Amanda E. ; Smith, Jacquelyn A. ; Alvarez, Carolina ; Arbeeva, Liubov ; Renner, Jordan B. ; ... More +
Nelson, Amanda E. ; Smith, Jacquelyn A. ; Alvarez, Carolina ; Arbeeva, Liubov ; Renner, Jordan B. ; Murphy, Louise B. ; Jordan, Joanne M. ; Golightly, Yvonne M. ; Duryea, Jeffrey Less -
Description:
Objective:

To evaluate quantitative joint space width (qJSW, at 10-, 30-, and 50-degree locations) in relation to incident radiographic and symptomatic hip osteoarthritis (rHOA and sxHOA, respectively) in a community-based cohort.

Methods:

Data were from Johnston County OA Project (JoCoOA) participants with supine hip radiographs at each of 4 timepoints; all had Kellgren-Lawrence grades (KLG) and qJSW. We assessed covariates (age, race, height, weight, body mass index [BMI]) associated with qJSW, and hip-level associations between qJSW and HOA, over time using sex-stratified and multivariable-adjusted linear mixed models. A cluster analysis with logistic regression estimated associations between qJSW trajectory groups and incident rHOA and sxHOA.

Results:

At baseline, 397 participants (784 hips, 41% men, 24% Black, mean age=57 years) had a mean BMI=29 kilograms/meter2. Over a mean of 18 years, 20% and 12% developed incident KLG-defined rHOA or sxHOA, respectively. QJSW was more sensitive to changes over time at 50 degrees. Values were stable among men but declined over time in women. Heavier women lost more qJSW; changes in qJSW were not significantly associated with race, education, or injury in women or men. In women only, loss of qJSW over time was associated with 2–3 times higher odds of rHOA and sxHOA; among women and men, narrower baseline qJSW was associated with these outcomes.

Conclusion:

Hip qJSW demonstrates marked sex differences, with significant loss over time only in women. Loss of qJSW over time in women, and narrower baseline qJSW in men and women, was associated with incident rHOA and sxHOA.


Subjects:
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Body Mass Index Female Hip Joint Humans Male Middle Aged Osteoarthritis, Hip Radiography
Source:
Arthritis Care Res (Hoboken). 74(12):1978-1988
Pubmed ID:
34219398
Pubmed Central ID:
PMC8727661
Document Type:
Journal Article
Funding:
U01 DP006266/DP/NCCDPHP CDC HHSUnited States/ ; P60 AR030701/AR/NIAMS NIH HHSUnited States/ ; U01DP003206/CC/CDC HHSUnited States/ ; U01DP006266/ACL/ACL HHSUnited States/ ; P60 AR064166/AR/NIAMS NIH HHSUnited States/ ; ... More +
U01 DP006266/DP/NCCDPHP CDC HHSUnited States/ ; P60 AR030701/AR/NIAMS NIH HHSUnited States/ ; U01DP003206/CC/CDC HHSUnited States/ ; U01DP006266/ACL/ACL HHSUnited States/ ; P60 AR064166/AR/NIAMS NIH HHSUnited States/ ; P30 AR072580/AR/NIAMS NIH HHSUnited States/ ; P60 AR049465/AR/NIAMS NIH HHSUnited States/ ; U01 DP003206/DP/NCCDPHP CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:efa22e5c8847dedcd781bcb314c9d3a4d1467b78e5898254809a0e47e18de51e
File Type:

• Supporting Files:
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