Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2011.131215
Personal Author:
Ardanuy, Carmen ; de la Campa, Adela G. ; García, Ernesto ; Fenoll, Asunción ; Calatayud, Laura ; ... More +
Ardanuy, Carmen ; de la Campa, Adela G. ; García, Ernesto ; Fenoll, Asunción ; Calatayud, Laura ; Cercenado, Emilia ; Pérez-Trallero, Emilio ; Bouza, Emilio ; Liñares, Josefina Less -
Description:
Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain.
Subject:
[+]
Antimicrobial Resistance
Bacteria
Dissemination
Fluoroquinolone Resistance
Multidrug-resistant Recombinant Clone
Research
Serotype 8-ST63
Spain
Spread
Spread Of Streptococcus Pneumoniae Serotype 8-ST63 Multidrug-Resistant Recombinant Clone, Spain
Streptococcus Pneumoniae
Sweden 15A-ST63 Clone

Source:
Emerg Infect Dis. 20(11):1848-1856.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:26c06f649169c7406716665510a7f431174006c1156febb594124f7616bdf62e
File Type:

Supporting Files

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