The Emergent Invasive Serotype 4 ST10172 Strain Acquires VanG-Type Vancomycin-Resistance Element: a Case of a 66-Year-Old With Bacteremic Pneumococcal Pneumonia.

Details

• Alternative Title:
  The Journal of Infectious Diseases, 2025, v. 231, no. 3: The Emergent Invasive Serotype 4 ST10172 Strain Acquires VanG-Type Vancomycin-Resistance Element: a Case of a 66-Year-Old With Bacteremic Pneumococcal Pneumonia.
• Journal Article:
  The Journal of Infectious Diseases
• Personal Author:
  Chochua, Sopio ; Beall, Bernard ; Lin, Wuling ; Tran, Theresa ; Rivers, Joy ; Li, Zhongya ; Arvay, Melissa L. ; Kobayashi, Miwako ; Houston, Jessica ; Arias, Sabra ; McGee, Lesley
• Description:
  We report a single case of invasive pneumococcal disease (IPD) by serotype 4, multilocus sequence type 10172 (ST10172) isolate with vanG-type resistance genes and reduced vancomycin susceptibility. The isolate was recovered during 2022 from a 66-year-old resident with bacteremic pneumococcal pneumonia within a Centers for Disease Control and Prevention Active Bacterial Core surveillance (ABCs) site hospital. The patient had received 23-valent pneumococcal polysaccharide vaccine and there was no evidence of concurrent or prior receipt of vancomycin in the previous year. Serotype 4/ST10172 IPD has shown increases within western ABCs sites, and the recent acquisition of a vanG element warrants close monitoring of this lineage.
• Content Notes:
  Author manuscript
• Subjects:
  • Aged
  • Humans
  • Anti-Bacterial Agents
  • Bacteremia
  • Bacterial Proteins
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • Pneumococcal Vaccines
  • Pneumonia, Pneumococcal
  • Serogroup
  More +
• Keywords:
  • Streptococcus pneumoniae
  • invasive pneumococcal disease
  • antibiotics
  • vancomycin resistance
  • emergent lineages
• Source:
  The Journal of Infectious Diseases, 2025, v. 231, no. 3
• DOI:
  https://doi.org/10.1093/infdis/jiae393
• ISSN:
  0022-1899 ; 1537-6613
• Pubmed ID:
  39116351
• Pubmed Central ID:
  PMC13067368
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; CC/CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  746-750 (9 pdf pages)
• Volume:
  231
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/262059/cdc_262059_DS1.pdf
• File Type:
  [PDF - 733.78 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:ef34eb0b0300c261fdb8e32f0bf7cabbff049866f1d72982d14d597b6d65bb79a06920292f04a930d75f52bd1f88d042398326bcb11b1b1b97e7428f1b810a1e