Hantavirus Infection, Non-Hantavirus Pulmonary Syndrome: 2015 Case Definition
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2021/04/16
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Description:NOTE: A surveillance case defi nition is a set of uniform criteria used to defi ne a disease for public health surveillance.Surveillance case defi nitions enable public health offi cials to classify and count cases consistently across reportingjurisdictions. Surveillance case defi nitions are not intended to be used by healthcare providers for making a clinicaldiagnosis or determining how to meet an individual patient’s health needs.
CSTE Position Statement(s): 14-ID-08
Background: Hantaviruses are pathogens carried by, and transmitted to humans, from rodents. Humans can contract hantavirus infectionwhen they come into contact with infected rodents or their urine and droppings. Patients with hantavirus infection typically present in a nonspecifi c way with a relatively short febrile prodrome lasting 3-5days. In addition to fever and myalgias, early symptoms include headache, chills, dizziness, non- productive cough, nausea,vomiting, and other gastrointestinal symptoms. Malaise, diarrhea, and lightheadedness are reported by approximately halfof all patients, with less frequent reports of arthralgias, back pain, and abdominal pain. Progression to cardio-pulmonarysymptoms occurs in most patients, consistent with Hantavirus pulmonary syndrome (HPS). A positive serological test result on an assay using a hantavirus antigen appropriate to the geographic region, evidence ofviral antigen in tissue by immunohistochemistry, or the presence of viral RNA in blood or tissue, with compatible history, isconsidered diagnostic for hantavirus infection.
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