Passive Surveillance for Azole-Resistant Aspergillus fumigatus, United States, 2011–2013

Pham, Cau D.; Reiss, Errol; Hagen, Ferry; Meis, Jacques F.; Lockhart, Shawn R.

doi:10.3201/eid2009.140142

i

Passive Surveillance for Azole-Resistant Aspergillus fumigatus, United States, 2011–2013

Supporting Files Public Domain

Sep 2014
By Pham, Cau D. ; Reiss, Errol ; Hagen, Ferry ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Pham, Cau D. ; Reiss, Errol ; Hagen, Ferry ; Meis, Jacques F. ; Lockhart, Shawn R.
Description:

Emergence of Aspergillus fumigatus strains containing mutations that lead to azole resistance has become a serious public health threat in many countries. Nucleotide polymorphisms leading to amino acid substitutions in the lanosterol demethylase gene (cyp51A) are associated with reduced susceptibility to azole drugs. The most widely recognized mutation is a lysine to histidine substitution at aa 98 (L98H) and a duplication of the untranscribed promoter region, together known as TR34/L98H. This mechanism of resistance has been reported in Europe, Asia, and the Middle East, and is associated with resistance to all azole drugs and subsequent treatment failures. To determine whether isolates with this mutation are spreading into the United States, we conducted a passive surveillance-based study of 1,026 clinical isolates of A. fumigatus from 22 US states during 2011-2013. No isolates harboring the TR34/L98H mutation were detected, and MICs of itraconazole were generally low.
Subjects:

Amino Acid Substitution Antifungal Agents/pharmacology Aspergillosis/epidemiology Aspergillosis/history Aspergillosis/microbiology Aspergillus Fumigatus Azoles / Pharmacology Cytochrome P-450 Enzyme System Drug Resistance, Fungal Fungal Proteins Geography, Medical History, 21st Century Humans Microbial Sensitivity Tests Mutation Population Surveillance Research
Source:

Emerg Infect Dis. 20(9):1498-1503.
Document Type:

Journal Article
Place as Subject:

United States
Location:

North America
Volume:

20
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:f49dfadd452c096b1d10ed3eee46a44a620fbd4a7f361bee52fd55679fe492e1
Download URL:

https://stacks.cdc.gov/view/cdc/25484/cdc_25484_DS1.pdf
File Type:

[PDF - 414.14 KB ]

File Language:

English

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