Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bradley, Kennedy ; Le-Mahajan, Audrey ; Morris, Beth ; Peritz, Tiina ; Chiller, Tom ; Forsberg, Kaitlin ; Nunnally, Natalie S. ; Lockhart, Shawn R. ; Gold, Jeremy A.W. ; Gould, Jane M.
• Description:
  We report a fatal infection in a 65-year-old immunocompromised male patient caused by pan-triazole-resistant Aspergillus fumigatus containing a TR|/L98H genetic mutation linked to agricultural fungicide use. Clinical and environmental surveillance of triazole-resistant A. fumigatus is needed in the United States to prevent spread and guide healthcare and agricultural practices.
• Subjects:
  Aged Antifungal Agents Azoles Cytochrome P-450 Enzyme System Drug Resistance, Fungal Fungal Proteins Fungicides, Industrial Humans Male Microbial Sensitivity Tests Triazoles

  More +
• Source:
  Emerg Infect Dis. 2022; 28(9):1904-1905
• Pubmed ID:
  35997507
• Pubmed Central ID:
  PMC9423893
• Document Type:
  Journal Article
• Genre:
  Letter
• Place as Subject:
  Pennsylvania
• Volume:
  28
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8c01007f1947b16ac87327bf3c8107ad6dea39de4b32c9905e0be061da97a400
• Download URL:
  https://stacks.cdc.gov/view/cdc/121053/cdc_121053_DS1.pdf
• File Type:
  [PDF - 301.70 KB ]