Adaptations of interferon regulatory factor 3 with transition from terrestrial to aquatic life.

Details

• Personal Author:
  Angeletti M ; Hsu W-LN ; Majo N ; Moriyama EN ; Moriyama H ; Zhang L
• Description:
  Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and the major factors for the induction of interferons, a key component in vertebrate innate immunity. However, there is limited knowledge regarding the evolution and adaptation of those IRFs to the environments. Two unique motifs in IRF3 and 7 were identified. One motif, GASSL, is highly conserved throughout the evolution of IRF3 and 7 and located in the signal response domain. Another motif, DPHK, is in the DNA-binding domain. The ancestral protein of IRF3 and 7 seemed to possess the DPHK motif. In the ray-finned fish lineage, while the DPHK is maintained in IRF7, the motif in IRF3 is changed to NPHK with a D --> N amino acid substitution. The D --> N substitution are also found in amphibian IRF3 but not in amphibian IRF7. Terrestrial animals such as reptiles and mammals predominantly use DPHK sequences in both IRF3 and 7. However, the D --> N substitution in IRF3 DPHK is again found in cetaceans such as whales and dolphins as well as in marsupials. These observations suggest that the D --> N substitutions in the IRF3 DPHK motif is likely to be associated with vertebrate's adaptations to aquatic environments and other environmental changes. [Description provided by NIOSH]
• Subjects:
  Animals Genetics Immune System Occupational Health Safety
• Keywords:
  Immunology; Immune reaction; Genes; Genetics; Immune system; Proteins; Animals; Amino acids
• ISSN:
  2045-2322
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  10
• NIOSHTIC Number:
  nn:20065149
• Citation:
  Sci Rep 2020 Mar; 10:4508
• Contact Point Address:
  Etsuko N. Moriyama, School of Biological Sciences, University of Nebraska, Lincoln, NE, 68588, USA
• Email:
  emoriyama2@unl.edu
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Scientific Reports
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9abe9744fd0ab2d4c30559bf747dcaa4f178eafd2356f64e8e2675a8e6e7d35813f7d050684386034e5dbd219435cb43e31616bbf80bd1943bbda7c7df3f5daf
• Download URL:
  https://stacks.cdc.gov/view/cdc/248603/cdc_248603_DS1.pdf
• File Type:
  [PDF - 3.65 MB ]