Neurobehavioral effects of methyl n-butyl ketone and methyl n-amyl ketone in rats and monkeys: a summary of NIOSH investigations.

Details

• Personal Author:
  Anger W ; Johnson BL ; Lewis TR ; Lynch DW ; Setzer JV
• Description:
  The neurophysiological and behavioral effects in monkeys and rats of methyl-n-butyl-ketone (591786) (MBK) and methyl-n-amyl-ketone (110430) (MAK) were studied. Male albino Sprague-Dawley-rats and male Macaca-fascicularis-monkeys inhaled MBK and MAK at concentrations of 0, 100, or 1,000 parts per million (ppm) for hours per day, 5 days per week for up to 10 months. While exposure to 1,000 ppm MAK for 9 months was nontoxic, exposure to 1,000 ppm MBK [Description provided by NIOSH]
• Subjects:
  Behavior Laboratories Nervous System Diseases Occupational Health Safety Solvents Toxicology
• Keywords:
  NIOSH-Author; Organic-solvents; Comparative-toxicology; Laboratory-animals; Behavioral-tests; Exposure-limits; Nervous-system-disorders
• ISSN:
  0146-4779
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  113-133
• Volume:
  2
• Issue:
  5
• NIOSHTIC Number:
  nn:00120856
• Citation:
  J Environ Pathol Toxicol 1979 May/Jun; 2(5):113-133
• CAS Registry Number:
  2-Heptanone (CAS RN 110-43-0) ; 2-Hexanone (CAS RN 591-78-6)
• Editor(s):
  Bridbord K; French J
• Federal Fiscal Year:
  1979
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Environmental Pathology and Toxicology. Toxicological and Carcinogenic Health Hazards in the Workplace: proceedings of the First Annual NIOSH Scientific Symposium, Cincinnati, Ohio, April 1978
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247519/cdc_247519_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]