Effects of Methyl Butyl Ketone on Peripheral Nerves and Its Mechanism of Action [1977]

Details

• Personal Author:
  Asbury AK ; Brown MJ ; DeJesus CP ; Paradise CM ; Pleasure DF
• Description:
  The effects of methyl-n-butyl-ketone (591786) (MBK) and methyl-ethyl- ketone (78933) (MEK) on the peripheral nerves of rats were studied. Wistar-rats inhaled 60 to 1050 parts per million (ppm) of MBK or 1460 to 4740ppm of MEK for 6 hours per day, 5 days per week for 4 to 6 weeks; rats were exposed to MBK until overt signs of neuropathy were evident. Electrophysiological, biochemical, and morphological examinations were performed. No animals exposed to MBK or MEK developed overt neuropathy by 6 weeks. Clinical signs of neuropathy became noticable at 9 to 10 weeks of MBK exposure. All MBK treated rats developed neuropathy by weeks 11 to 13. No neuropathic effects were seen in rats exposed to MEK. The authors conclude that MBK causes neuropathy while MEK does not. [Description provided by NIOSH]
• Subjects:
  Biochemistry Laboratories Nervous System Diseases Occupational Health Safety Solvents Toxicology
• Keywords:
  Biochemical-analysis Contract-099-76-0016 Laboratory-animals Nervous-system-disorders NIOSH-Contract Organic-solvents
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-41
• NIOSHTIC Number:
  nn:00120689
• NTIS Accession Number:
  PB83-105148
• Citation:
  NIOSH; :1-41
• CAS Registry Number:
  2-Hexanone (CAS RN 591-78-6) ; Methyl ethyl ketone (CAS RN 78-93-3)
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a048bbb366c3dceb4f2639db85e31cbb10718cd3043f6a066c79133ca68c02d76d94aa67dda17acba6437593099859fffc4f175d3c5567c22ec4f4297be90123
• Download URL:
  https://stacks.cdc.gov/view/cdc/184512/cdc_184512_DS1.pdf
• File Type:
  [PDF - 1.83 MB ]