Some effects of sub-acute exposure to toluene on schedule-controlled behavior.

Details

• Personal Author:
  Glowa JR
• Description:
  Some behavioral effects of different concentrations and duration of exposure to toluene (108883) were studied in mice. Male Charles-River-CD-1-white-mice were exposed to 500, 1000 or 2000 parts per million (ppm) of toluene for the last 4 hours of 5 consecutive days and their responses recorded and compared with a control series. Exposure occurred in a hermetically sealed chamber where the mice received milk on a 60 second schedule of presentation and toluene was introduced. An inner chamber contained a light beam and a photocell, a cup which could be filled with milk three small lights to serve as visual stimuli and a speaker which could provide white noise. A response was recorded when the mouse seeking milk interrupted the light beam. Milk was delivered in the presence of flashing lights. White noise was providing during time outs and before and after sessions when milk was provided. Exposure ran from 25 minutes to 4 hours. Sessions consisted of alternating 10 minute periods when milk was available under the schedule and 25 minute periods when responding had no scheduled consequences. Repeated exposure to 500ppm of toluene for 4 hours a day for 5 days had little behavioral effect. Repeated exposure to 1000ppm resulted in both a sustained increase in responding during each session and each day of repeated exposure. At 2000ppm, slightly longer exposure durations were required to produce a consistent behavioral effect but responses ceased after about 2 hours exposure. The authors conclude that consistent concentration dependent effects of toluene occurred over 4 hour exposure periods with schedule controlled responding in mice. [Description provided by NIOSH]
• Subjects:
  Behavior Laboratories Nervous System Nervous System Diseases Occupational Health Safety Solvents Toluene Toxicology
• Keywords:
  Author Keywords: Toluene Behavioral Tests Conditioned Responses Laboratory Animals Mice Nervous System Disorders Neurotoxicity Organic Solvents Schedule-controlled Responding Sub-acute Exposure
• ISSN:
  0275-1380
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  463-465
• Volume:
  3
• Issue:
  4
• NIOSHTIC Number:
  nn:00124667
• Citation:
  Neurobehav Toxicol Teratol 1981 Winter; 3(4):463-465
• CAS Registry Number:
  Toluene (CAS RN 108-88-3)
• Federal Fiscal Year:
  1982
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19780501
• Source Full Name:
  Neurobehavioral Toxicology and Teratology
• End Date:
  19840430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ca88e91b8fee3c46399927b72655a48f73e739db3f3c166dbe1a99bb39a6ce60598ef6af204f12819601e27ded6ac51ab63b7125af642d7518e56593e23be8a2
• Download URL:
  https://stacks.cdc.gov/view/cdc/184568/cdc_184568_DS1.pdf
• File Type:
  [PDF - 686.80 KB ]