The distribution and retention of selected metals in rat tissue after inhalation of cadmium oxide aerosols.

Details

• Personal Author:
  Blackstone M ; Kaplan PD ; Richdale N
• Description:
  The retention and distribution of cadmium (7440439), zinc (7440666), and copper (7440508) are measured as a function of exposure level and time as part of a study to determine the binding of cadmium ions to cellular components of the lung and kidney after inhalation of cadmium oxide aerosol. Animal tissues are analyzed with the aid of atomic absorption spectrophotometry. The retention of cadmium is found to be related to the ambient concentration within the inhalation chamber. Homogenization of each organ, followed by subcellular fractionation through differential centrifugation, is used to demonstrate the steady increase in concentration of all three metals within the cytoplasm of the cell. The concentrations of the metals in each organ are primarily related to the length of the exposure. [Description provided by NIOSH]
• Subjects:
  Cytology Kidney Diseases Lung Diseases Metals Metals, Heavy Occupational Health Poisoning Safety Urogenital Diseases Urogenital System
• Keywords:
  NIOSH-Grant; Trace-metals; Heavy-metals; Metal-poisoning; Metal-particulates; Kidney-disorders; Analytical-methods; Cytopathology; Lung-disorders
• ISBN:
  9780387069968
• Publisher:
  Springer-Verlag
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-11
• NIOSHTIC Number:
  nn:00036277
• Citation:
  Experimental Lung Cancer: Carcinogenesis and Bioassays: International Symposium on Experimental Respiratory Carcinogenesis and Bioassays held at the Battelle Seattle Research Center, Seattle, Washington, USA, June 23-26, 1974. Karbe E, Park JF, eds., New York: Springer-Verlag, 1974 Jun; :1-11
• Contact Point Address:
  Environmental Health University of Cincinnati Eden and Bethesda Avenues Cincinnati, Ohio 45219
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9) ; Copper (CAS RN 7440-50-8) ; Zinc (CAS RN 7440-66-6)
• Editor(s):
  Karbe E; Park JF
• Federal Fiscal Year:
  1974
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  False
• Start Date:
  19710401
• Source Full Name:
  Experimental Lung Cancer: Carcinogenesis and Bioassays: International Symposium on Experimental Respiratory Carcinogenesis and Bioassays held at the Battelle Seattle Research Center, Seattle, Washington, USA, June 23-26, 1974
• End Date:
  19760531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/241751/cdc_241751_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]