Aminoaciduria and proteinuria in rats after a single intraperitoneal injection of Ni(II).

Details

• Personal Author:
  Gitlitz PH ; Goldblatt PJ ; Sunderman FW Jr.
• Description:
  Proteinuria was found in Fischer female rats after single intraperitoneal injection of nickel (7440020) chloride (7718549) in dosages from 34 to 85 micromoles per kilogram. Generalized alpha- aminoaciduria was found after a single intraperitoneal injection of nickel-chloride in dosages of 68 and 85 micromoles per kilogram. Amino acids in plasma were normal or slightly diminished from 1 to 48 hours after injection of nickel-chloride. Electron microscopy of kidneys of five rats at 48 hour after nickel-chloride (68 micromoles per kilogram) consistently revealed fusion of foot processes of glomerular epithelial cells. Focal tubular necrosis was present in the kidney of one of these rats. This study demonstrates that toxic nephropathy with aminoaciduria and proteinuria develops in rats after intraperitoneal nickel-chloride. Amino acid and protein excretions consistently returned to normal by Day 5. [Description provided by NIOSH]
• Subjects:
  Cytology Kidney Diseases Metals Metals, Heavy Nickel Occupational Health Poisoning Safety Urine Urogenital Diseases Urogenital System

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• Keywords:
  Contract-099-72-0024 Heavy-metal-poisoning Heavy-metals Kidney-disorders Nephrotoxicity Nickel-compounds NIOSH-Contract NIOSH-Publication Urinary-output Urinary-proteins Urine-chemistry

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• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  430-440
• Volume:
  34
• Issue:
  3
• NIOSHTIC Number:
  nn:00053981
• Citation:
  Toxicol Appl Pharmacol 1975 Dec; 34(3):430-440
• CAS Registry Number:
  Nickel (CAS RN 7440-02-0) ; Nickel dichloride (CAS RN 7718-54-9)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f254953d98c364712d66a5384f62e830bcb3cdcc5f4db817f70618004468697a945e366b54533c72a5a59516e043b17ce0208ae92e7a8c7c6f4c79615a1f6897
• Download URL:
  https://stacks.cdc.gov/view/cdc/184089/cdc_184089_DS1.pdf
• File Type:
  [PDF - 1.73 MB ]