Binding of bismuth in the kidneys of the rate: The role of metallothionein-like proteins.

Details

• Personal Author:
  Kaszper BW ; Mogilnicka EM ; Szymanska JA
• Description:
  Experiments were carried out in female rats injected subcutaneously with bismuth (7440699), in the form of radioactive labeled bismuth- chloride (7787602), in order to determine whether the level of metallothionein like proteins is elevated by repeated administration of the metal. According to the results obtained it follows that the elevated capacity of kidneys for bismuth, observed when the metal is administered repeatedly, is connected with metallothionein like proteins the level of which is enhanced by this element. Whether these proteins are identical with those which aid the storage of mercury in the kidneys requires further studies. [Description provided by NIOSH]
• Subjects:
  Biochemistry Kidney Diseases Metals Metals, Heavy Occupational Health Poisoning Safety Toxicology Urogenital Diseases Urogenital System
• Keywords:
  Heavy-metals Metal-poisoning Metalloproteins Nephrotoxicity NIOSH-Grant NIOSH-Publication Protein-binding
• ISSN:
  0006-2952
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  257-258
• Volume:
  26
• Issue:
  3
• NIOSHTIC Number:
  nn:00071634
• Citation:
  Biochem Pharmacol 1977 Feb; 26(3):257-258
• CAS Registry Number:
  Bismuth (CAS RN 7440-69-9) ; Bismuth trichloride (CAS RN 7787-60-2)
• Federal Fiscal Year:
  1977
• Peer Reviewed:
  True
• Source Full Name:
  Biochemical Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a5a6abc0324dfe3148f78f8beb87e99a53e3e8fc8874ea96407f531c2d267d310ea35d93dfa3546d0cebabee6b7c0246903a600854d546ce472acbcb9ea324bd
• Download URL:
  https://stacks.cdc.gov/view/cdc/184189/cdc_184189_DS1.pdf
• File Type:
  [PDF - 140.46 KB ]