MHC associations with clinical and autoantibody manifestations in European SLE

Morris, DL; Fernando, MMA; Taylor, KE; Chung, SA; Nititham, J; Alarcón-Riquelme, ME; Barcellos, LF; Behrens, TW; Cotsapas, C; Gaffney, PM; Graham, RR; Pons-Estel, BA; Gregersen, PK; Harley, JB; Hauser, SL; Hom, G; Langefeld, CD; Noble, JA; Rioux, JD; Seldin, MF; Vyse, TJ; Criswell, LA

doi:10.1038/gene.2014.6

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MHC associations with clinical and autoantibody manifestations in European SLE

Published Date:

Mar 06 2014

Publisher's site:

http://dx.doi.org/10.1038/gene.2014.6 New Site Icon

Source:

Genes Immun. 2014; 15(4):210-217.

[PDF-324.50 KB]

Details:

Alternative Title:

Genes Immun

Personal Author:

Morris, DL ; Fernando, MMA ; Taylor, KE ; Chung, SA ; Nititham, J ; ... More ▼

Corporate Authors:

Systemic Lupus Erythematosus Genetics Consortium

Description:

Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease affecting multiple organ systems and characterized by autoantibody formation to nuclear components. Although genetic variation within the major histocompatibility complex (MHC) is associated with SLE, its role in the development of clinical manifestations and autoantibody production is not well defined. We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. Of the 11 American College of Rheumatology criteria and 7 autoantibody sub-phenotypes examined, anti-Ro/SSA and anti-La/SSB antibody subsets exhibited the highest number and most statistically significant associations. HLA-DRB1*03:01 was significantly associated with both sub-phenotypes. We found evidence of associations independent of MHC class II variants in the anti-Ro subset alone. Conditional analyses showed that anti-Ro and anti-La subsets are independently associated with HLA-DRB1*0301, and that the HLA-DRB1*03:01 association with SLE is largely but not completely driven by the association of this allele with these sub-phenotypes. Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies.

Subject:

[+]

Pubmed ID:

24598797

Pubmed Central ID:

PMC4102853

Document Type:

Journal Article

Funding:

076113/Wellcome Trust/United Kingdom ; 085475/Wellcome Trust/United Kingdom ; 17761/PI/Arthritis Research UK/United Kingdom ; 18239/Arthritis Research UK/United Kingdom ; 5 M01 RR-00079/RR/NCRR NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

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Supporting Files:

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	nihms595460f1.jpg	image/jpeg

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