Long-term opioid therapy among patients with systemic lupus erythematosus in the community. A Lupus Midwest Network study

Details

• Alternative Title:
  J Rheumatol
• Personal Author:
  Figueroa-Parra, Gabriel ; Jeffery, Molly M. ; Dabit, Jesse Y. ; Chevet, Baptiste ; Valenzuela-Almada, Maria O. ; Hocaoglu, Mehmet ; Osei-Onomah, Shirley-Ann ; Kurani, Shaheen ; Vallejo, Sebastian ; Achenbach, Sara J. ; Hooten, W. Michael ; Barbour, Kamil E. ; Crowson, Cynthia S. ; Duarte-García, Alí
  More +
• Description:
  Objective ; There is little information about the epidemiology and factors associated with opioid therapy in systemic lupus erythematosus (SLE). We aimed to assess the prevalence of opioid therapy and explore factors associated with long-term opioid therapy (LTOT) in patients with SLE. ; Methods ; Patients with SLE were matched with non-SLE controls in a population-based cohort on January 1, 2015. We captured demographics, manifestations of lupus, comorbidities (fibromyalgia, mood disorders, osteoarthritis, chronic low back pain CLBP, chronic kidney disease, avascular necrosis, osteoporosis, fragility fractures, and cancer), and the area deprivation index (ADI). Opioid prescription data were used to assess prevalence of LTOT, defined as contiguous prescriptions (gaps of <30 days between prescriptions) and receiving opioid therapy ≥90 days or ≥10 prescriptions before index date. ; Results ; 465 SLE patients and 465 non-SLE controls were included; 13% of SLE patients and 3% of non-SLE controls were receiving opioid therapy (P<0.001), and 11% of SLE patients were on LTOT versus 1% of non-SLE controls. Among SLE patients, acute pericarditis (OR: 3.92; 95% CI: 1.78–8.66), fibromyalgia (OR: 7.78; 95% CI: 3.89–15.55), fragility fractures (OR: 3.72; 95% CI: 1.25–11.07), CLBP (OR: 4.00; 95% CI: 2.13–7.51), and mood disorders (OR: 2.76; 95% CI: 1.47–5.16) were associated with LTOT. We did not find an association between opioid therapy and ADI. ; Conclusion ; Patients with SLE have higher LTOT than controls. Among patients with SLE, LTOT was associated with pericarditis and several comorbidities. However, LTOT was not associated with kidney disease despite the limited pain control options in these patients.
• Subjects:
  • Humans
  • Analgesics, Opioid
  • Retrospective Studies
  • Fibromyalgia
  • Lupus Erythematosus, Systemic
  • Pericarditis
  • Fractures, Bone
• Keywords:
  • Systemic lupus erythematosus
  • opioids
  • pain management
  • long-term opioid therapy
  • comorbidity
• Source:
  J Rheumatol. 50(4):504-511
• Pubmed ID:
  36379579
• Pubmed Central ID:
  PMC10066823
• Document Type:
  Journal Article
• Funding:
  U01DP006491/ACL/ACL HHSUnited States/ ; UL1 TR002377/TR/NCATS NIH HHSUnited States/ ; R01 AG034676/AG/NIA NIH HHSUnited States/ ; U01 DP006491/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP006703/DP/NCCDPHP CDC HHSUnited States/ ; R33 AG058738/AG/NIA NIH HHSUnited States/
• Volume:
  50
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/126399/cdc_126399_DS1.pdf
• File Type:
  [PDF - 342.12 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a4d4dd54293d29bcbf950a957ef32d312286da6c29a26d596d9899acf4f10819