Occurrence, Transmission, and Zoonotic Potential of Chronic Wasting Disease
Published Date:Mar 2012
Source:Emerg Infect Dis. 18(3):369-376.
Bovine Spongiform Encephalopathy
Chronic Wasting Disease
Prions And Related Diseases
Transmissible Spongiform Encephalopathy
Wasting Disease, Chronic
Funding:2R01 NS052609/NS/NINDS NIH HHS/United States
C06 RR17417-01/RR/NCRR NIH HHS/United States
G20RR024001/RR/NCRR NIH HHS/United States
P20 RR0115635-6/RR/NCRR NIH HHS/United States
Description:Chronic wasting disease (CWD) is a fatal, transmissible prion disease that affects captive and free-ranging deer, elk, and moose. Although the zoonotic potential of CWD is considered low, identification of multiple CWD strains and the potential for agent evolution upon serial passage hinders a definitive conclusion. Surveillance for CWD in free-ranging populations has documented a continual geographic spread of the disease throughout North America. CWD prions are shed from clinically and preclinically affected hosts, and CWD transmission is mediated at least in part by the environment, perhaps by soil. Much remains unknown, including the sites and mechanisms of prion uptake in the naive host. There are no therapeutics or effective eradication measures for CWD-endemic populations. Continued surveillance and research of CWD and its effects on cervid ecosystems is vital for controlling the long-term consequences of this emerging disease.
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