Influenza B Viruses with Mutation in the Neuraminidase Active Site, North Carolina, USA, 2010–11

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sleeman, Katrina ; Sheu, Tiffany G. ; Moore, Zack ; Kilpatrick, Susan ; Garg, Shikha ; Fry, Alicia M. ; Gubareva, Larisa V.
• Description:
  Oseltamivir is 1 of 2 antiviral medications available for the treatment of influenza B virus infections. We describe and characterize a cluster of influenza B viruses circulating in North Carolina with a mutation in the neuraminidase active site that may reduce susceptibility to oseltamivir and the investigational drug peramivir but not to zanamivir.
• Subjects:
  Adolescent Adult Antiviral Agents Catalytic Domain Child Child, Preschool Cyclopentanes Dispatch Drug Resistance, Viral Guanidines Hemagglutinin Glycoproteins, Influenza Virus Humans Infant Influenza, Human Influenza B Virus Microbial Sensitivity Tests Middle Aged Mutation Neuraminidase Oseltamivir Phylogeny Polymorphism, Single Nucleotide Young Adult

  More +
• Source:
  Emerg Infect Dis. 17(11):2043-2046.
• Document Type:
  Journal Article
• Place as Subject:
  North Carolina
• Location:
  North America
• Volume:
  17
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:496c78daed820391da3a2c8b2bcde5d18bc135b946d93a2a914192d52cc00716
• Download URL:
  https://stacks.cdc.gov/view/cdc/23735/cdc_23735_DS1.pdf
• File Type:
  [PDF - 303.27 KB ]