Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Bouquet, Jérôme ; Tessé, Sophie ; Lunazzi, Aurélie ; Eloit, Marc ; Rose, Nicolas ; ... More +
Bouquet, Jérôme ; Tessé, Sophie ; Lunazzi, Aurélie ; Eloit, Marc ; Rose, Nicolas ; Nicand, Elisabeth ; Pavio, Nicole ; Less -
Description:
Frequent zoonotic transmission of hepatitis E virus (HEV) has been suspected, but data supporting the animal origin of autochthonous cases are still sparse. We assessed the genetic identity of HEV strains found in humans and swine during an 18-month period in France. HEV sequences identified in patients with autochthonous hepatitis E infection (n = 106) were compared with sequences amplified from swine livers collected in slaughterhouses (n = 43). Phylogenetic analysis showed the same proportions of subtypes 3f (73.8%), 3c (13.4%), and 3e (4.7%) in human and swine populations. Furthermore, similarity of >99% was found between HEV sequences of human and swine origins. These results indicate that consumption of some pork products, such as raw liver, is a major source of exposure for autochthonous HEV infection.
Subject:
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Adult
Aged
Animals
CME
Female
France
Genotype
Hepatitis E
Hepatitis E Virus
Humans
Male
Middle Aged
Molecular Sequence Data
Phylogeny
Phylogeography
Research
RNA, Viral
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Swine
Swine Diseases
Viral Proteins

Source:
Emerg Infect Dis. 17(11):2018-2025. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:c011c9c6fc8ae8d3b5076b6df265436de98f40fe0539256882482e9f52b85cb2
File Type:

Supporting Files

• 	11-0616_finalRCME_PMC.nxml	txt
  	license.txt	txt
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