Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Bouquet, Jérôme ; Tessé, Sophie ; Lunazzi, Aurélie ; Eloit, Marc ; Rose, Nicolas ; ... More +
Bouquet, Jérôme ; Tessé, Sophie ; Lunazzi, Aurélie ; Eloit, Marc ; Rose, Nicolas ; Nicand, Elisabeth ; Pavio, Nicole Less -
Description:
Frequent zoonotic transmission of hepatitis E virus (HEV) has been suspected, but data supporting the animal origin of autochthonous cases are still sparse. We assessed the genetic identity of HEV strains found in humans and swine during an 18-month period in France. HEV sequences identified in patients with autochthonous hepatitis E infection (n = 106) were compared with sequences amplified from swine livers collected in slaughterhouses (n = 43). Phylogenetic analysis showed the same proportions of subtypes 3f (73.8%), 3c (13.4%), and 3e (4.7%) in human and swine populations. Furthermore, similarity of >99% was found between HEV sequences of human and swine origins. These results indicate that consumption of some pork products, such as raw liver, is a major source of exposure for autochthonous HEV infection.
Subjects:
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Adult Aged Animals Cme Female France Genotype Hepatitis E Hepatitis E Virus Humans Male Middle Aged Molecular Sequence Data Phylogeny Phylogeography Research Rna, Viral Sequence Analysis, DNA Sequence Homology, Nucleic Acid Swine Swine Diseases Viral Proteins
Source:
Emerg Infect Dis. 17(11):2018-2025.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:c011c9c6fc8ae8d3b5076b6df265436de98f40fe0539256882482e9f52b85cb2
Download URL:
https://stacks.cdc.gov/view/cdc/23726/cdc_23726_DS1.pdf
File Type:

Supporting Files

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