Genetic host specificity of hepatitis E virus

Details

• Alternative Title:
  Infect Genet Evol
• Personal Author:
  Lara, James ; Purdy, Michael A. ; Khudyakov, Yury E.
• Description:
  Hepatitis E virus (HEV) causes epidemic and sporadic cases of hepatitis worldwide. HEV genotypes 3 (HEV3) and 4 (HEV4) infect humans and animals, with swine being the primary reservoir. The relevance of HEV genetic diversity to host adaptation is poorly understood. We employed a Bayesian network (BN) analysis of HEV3 and HEV4 to detect epistatic connectivity among protein sites and its association with the host specificity in each genotype. The data imply coevolution among ∼70% of polymorphic sites from all HEV proteins and association of numerous coevolving sites with adaptation to swine or humans. BN models for individual proteins and domains of the nonstructural polyprotein detected the host origin of HEV strains with accuracy of 74-93% and 63-87%, respectively. These findings, taken together with lack of phylogenetic association to host, suggest that the HEV host specificity is a heritable and convergent phenotypic trait achievable through variety of genetic pathways (abundance), and explain a broad host range for HEV3 and HEV4.
• Subjects:
  Adaptation, Physiological Animals Base Sequence Bayes Theorem Genetic Variation Hepatitis E Hepatitis E Virus Host Specificity Humans Open Reading Frames Phylogeny Sequence Alignment Swine Swine Diseases Viral Nonstructural Proteins

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• Keywords:
  Adaptation Bayesian Network Coevolution HEV ORFs Prediction
• Source:
  Infect Genet Evol. 24:127-139
• Pubmed ID:
  24667049
• Pubmed Central ID:
  PMC5745802
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  24
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eb79c76fd7f31800734704fdeb78fd14277f9a3fd4d3179828ba26a8b02fbf6d
• Download URL:
  https://stacks.cdc.gov/view/cdc/50639/cdc_50639_DS1.pdf
• File Type:
  [PDF - 2.21 MB ]