Genetic host specificity of hepatitis E virus

Lara, James; Purdy, Michael A.; Khudyakov, Yury E.

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Genetic host specificity of hepatitis E virus

Published Date:

March 22 2014

Source:

Infect Genet Evol. 24:127-139

Language:

English

[PDF-2.21 MB]

Details:

Alternative Title:

Infect Genet Evol

Personal Author:

Lara, James ; Purdy, Michael A. ; Khudyakov, Yury E. ;

Description:

Hepatitis E virus (HEV) causes epidemic and sporadic cases of hepatitis worldwide. HEV genotypes 3 (HEV3) and 4 (HEV4) infect humans and animals, with swine being the primary reservoir. The relevance of HEV genetic diversity to host adaptation is poorly understood. We employed a Bayesian network (BN) analysis of HEV3 and HEV4 to detect epistatic connectivity among protein sites and its association with the host specificity in each genotype. The data imply coevolution among ∼70% of polymorphic sites from all HEV proteins and association of numerous coevolving sites with adaptation to swine or humans. BN models for individual proteins and domains of the nonstructural polyprotein detected the host origin of HEV strains with accuracy of 74-93% and 63-87%, respectively. These findings, taken together with lack of phylogenetic association to host, suggest that the HEV host specificity is a heritable and convergent phenotypic trait achievable through variety of genetic pathways (abundance), and explain a broad host range for HEV3 and HEV4.

Subject:

[+]

Pubmed ID:

24667049

Pubmed Central ID:

PMC5745802

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

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