Details:

Alternative Title:
Infect Genet Evol
Personal Author:
Lara, James ; Purdy, Michael A. ; Khudyakov, Yury E.
Lara, James ; Purdy, Michael A. ; Khudyakov, Yury E. Less -
Description:
Hepatitis E virus (HEV) causes epidemic and sporadic cases of hepatitis worldwide. HEV genotypes 3 (HEV3) and 4 (HEV4) infect humans and animals, with swine being the primary reservoir. The relevance of HEV genetic diversity to host adaptation is poorly understood. We employed a Bayesian network (BN) analysis of HEV3 and HEV4 to detect epistatic connectivity among protein sites and its association with the host specificity in each genotype. The data imply coevolution among ∼70% of polymorphic sites from all HEV proteins and association of numerous coevolving sites with adaptation to swine or humans. BN models for individual proteins and domains of the nonstructural polyprotein detected the host origin of HEV strains with accuracy of 74-93% and 63-87%, respectively. These findings, taken together with lack of phylogenetic association to host, suggest that the HEV host specificity is a heritable and convergent phenotypic trait achievable through variety of genetic pathways (abundance), and explain a broad host range for HEV3 and HEV4.
Subjects:
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Adaptation Adaptation, Physiological Animals Article Base Sequence Bayesian Network Bayes Theorem Coevolution Genetic Variation Hepatitis E Hepatitis E Virus HEV ORFs Host Specificity Humans Open Reading Frames Phylogeny Prediction Sequence Alignment Swine Swine Diseases Viral Nonstructural Proteins
Source:
Infect Genet Evol. 24:127-139
Pubmed ID:
24667049
Pubmed Central ID:
PMC5745802
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:eb79c76fd7f31800734704fdeb78fd14277f9a3fd4d3179828ba26a8b02fbf6d
Download URL:
https://stacks.cdc.gov/view/cdc/50639/cdc_50639_DS1.pdf
File Type:

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