Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1709.101403
Personal Author:
Torres, Juan-María ; Andréoletti, Olivier ; Lacroux, Caroline ; Prieto, Irene ; Lorenzo, Patricia ; ... More +
Torres, Juan-María ; Andréoletti, Olivier ; Lacroux, Caroline ; Prieto, Irene ; Lorenzo, Patricia ; Larska, Magdalena ; Baron, Thierry ; Espinosa, Juan-Carlos Less -
Description:
Bovine spongiform encephalopathy (BSE) and BSE-related disorders have been associated with a single major prion strain. Recently, 2 atypical, presumably sporadic forms of BSE have been associated with 2 distinct prion strains that are characterized mainly by distinct Western blot profiles of abnormal protease-resistant prion protein (PrPres), named high-type (BSE-H) and low-type (BSE-L), that also differed from classical BSE. We characterized 5 atypical BSE-H isolates by analyzing their molecular and neuropathologic properties during transmission in transgenic mice expressing homologous bovine prion protein. Unexpectedly, in several inoculated animals, strain features emerged that were highly similar to those of classical BSE agent. These findings demonstrate the capability of an atypical bovine prion to acquire classical BSE-like properties during propagation in a homologous bovine prion protein context and support the view that the epidemic BSE agent could have originated from such a cattle prion.
Subject:
[+]
Animals
Atypical BSE
Bovine Spongiform Encephalopathy
Brain
BSE
Cattle
Encephalopathy, Bovine Spongiform
H-type BSE
Mice
Mice, Transgenic
Origin Of BSE
Prions And Related Diseases
Prion Strain
Prion Transmission
PrP
PrPC Proteins
PrPSc Proteins
Research
Spleen
Research

Source:
Emerg Infect Dis. 17(9):1636-1644.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:923ed04c0532f63aea985768a91f1efdcfc504c13480809f63bbf538eec39a68
File Type:

Supporting Files

• 	10-1403-F5.gif	gif
  	10-1403-F5.jpg	jpeg
  	10-1403-F6.gif	gif
  	10-1403-F6.jpg	jpeg
  	10-1403-F7.gif	gif
  	10-1403-F7.jpg	jpeg
  	10-1403_finalR.nxml	txt
  	license.txt	txt
  	10-1403-F1.gif	gif
  	10-1403-F1.jpg	jpeg
  	10-1403-F2.gif	gif
  	10-1403-F2.jpg	jpeg
  	10-1403-F3.gif	gif
  	10-1403-F3.jpg	jpeg
  	10-1403-F4.gif	gif
  	10-1403-F4.jpg	jpeg

More +