Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1709.101403
Personal Author:
Torres, Juan-María ; Andréoletti, Olivier ; Lacroux, Caroline ; Prieto, Irene ; Lorenzo, Patricia ; ... More +
Torres, Juan-María ; Andréoletti, Olivier ; Lacroux, Caroline ; Prieto, Irene ; Lorenzo, Patricia ; Larska, Magdalena ; Baron, Thierry ; Espinosa, Juan-Carlos Less -
Description:
Bovine spongiform encephalopathy (BSE) and BSE-related disorders have been associated with a single major prion strain. Recently, 2 atypical, presumably sporadic forms of BSE have been associated with 2 distinct prion strains that are characterized mainly by distinct Western blot profiles of abnormal protease-resistant prion protein (PrPres), named high-type (BSE-H) and low-type (BSE-L), that also differed from classical BSE. We characterized 5 atypical BSE-H isolates by analyzing their molecular and neuropathologic properties during transmission in transgenic mice expressing homologous bovine prion protein. Unexpectedly, in several inoculated animals, strain features emerged that were highly similar to those of classical BSE agent. These findings demonstrate the capability of an atypical bovine prion to acquire classical BSE-like properties during propagation in a homologous bovine prion protein context and support the view that the epidemic BSE agent could have originated from such a cattle prion.
Subjects:
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Animals Atypical BSE Bovine Spongiform Encephalopathy Brain BSE Cattle Encephalopathy, Bovine Spongiform H-type BSE Mice Mice, Transgenic Origin Of BSE Prions And Related Diseases Prion Strain Prion Transmission PrP PrPC Proteins PrPSc Proteins Research Spleen
Source:
Emerg Infect Dis. 17(9):1636-1644.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:923ed04c0532f63aea985768a91f1efdcfc504c13480809f63bbf538eec39a68
Download URL:
https://stacks.cdc.gov/view/cdc/23666/cdc_23666_DS1.pdf
File Type:

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