Corrigendum to: Associations Between Maternal Plasma Measurements of Inflammatory Markers and Urinary Levels of Phenols and Parabens During Pregnancy: A Repeated Measures Study

Details

• Personal Author:
  Aung, M. T. ; Bakulski, K. M. ; Cantonwine, D. E. ; Ferguson, K. K. ; Loch-Caruso, R. ; McElrath, T. F. ; Meeker, John D. ; Mukherjee, B.
• Description:
  Background: Maternal immune system regulation is critical for maintenance of a healthy pregnancy and fetal development. Exposure to phenols and parabens is widespread, and may be linked to systemic inflammation and alteration of circulating immunological biomarkers. Objective: We sought to characterize associations between repeated measures of individual urinary phenols, parabens and plasma inflammatory markers across pregnancy. Methods: In the LIFECODES prospective birth cohort, we conducted a nested preterm birth case-control study, including 130 cases and 352 controls. In urine samples collected from each participant at up to four study visits during pregnancy, we measured concentrations of six phenols and four parabens, as well as five plasma inflammatory markers. We used multivariable linear mixed models to analyze repeated measures of exposures on inflammatory markers. We created and applied inverse probability weights to account for the sampling approach. Results: We observed bidirectional associations between select phenols and parabens and inflammatory markers. An interquartile range increase in triclosan (55.2 ng/mL) was associated with a 12.5% (95% CI: 3.67, 22.0) increase in C-reactive protein, a 7.95% (95% CI: 1.95, 14.3) increase in interleukin 10, and a 7.93% (95% CI: 3.82, 12,2) increase in tumor necrosis factor-a. Additionally, an interquartile range increase in 2,5-dichlorophenol (11.0 ng/mL) was associated with a 10% increase in C-reactive protein (95% CI: 1.92, 18.7). Conversely, an interquartile range increase in ethyl paraben (10.4 ng/mL) was associated with a 7.7% decrease in interleukin-1β (95% CI: -14.1, -0.86). Conclusions: Our findings can be organized into two thematic frameworks, one where concentrations of urinary phenols and parabens during pregnancy reflected a pro-inflammatory relationship with immunological biomarkers, and the other contrary theme - an anti-inflammatory relationship. These findings have implications for fetal development and reproductive outcomes, and emphasize the need for further research on immunological mechanisms of phenol and paraben action during pregnancy. Corrigendum: Sci Total Environ Mar 25 2019 658:1640. The authors regret an error that resulted in the reverse-coding of fetal sex. In Table 1we present the n(%) of the population that is carrying a male vs. a female fetus as well as the maternal urinary phenol/paraben concentrations by sex of the fetus. The labeling of these rows is reversed. [Description provided by NIOSH]
• Subjects:
  Biomarkers Immune System Occupational Health Phenol Pregnancy Safety
• Keywords:
  Author Keywords: Chlorinated Phenols; Cytokines; Reproductive Immunology Pregnancy; Prenatal Exposure; Phenols; Biomarkers; Immune Reaction; Biological Effects;
• ISSN:
  0048-9697
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; North Carolina ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1 pdf page
• NIOSHTIC Number:
  nn:20055693
• Citation:
  Sci Total Environ 2019 Feb; 650(Pt 1):1131-1140
• Contact Point Address:
  John D. Meeker, University of Michigan School of Public Health, Department of Environmental Health Sciences, 1835 SPH I, 1415 Washington Heights, Ann Arbor, MI 48109-2029, United States
• Email:
  meekerj@umich.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Part Number:
  1
• Start Date:
  20050701
• Source Full Name:
  Science of the Total Environment
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:032c3a68918820a4fde3063086177d6e6e247bb290e5e6ff3321696742ccbf910240925283c66b9d7d1855df6c49e6231390c0ef49da8bc127b6fd8eec737f82
• Download URL:
  https://stacks.cdc.gov/view/cdc/231531/cdc_231531_DS1.pdf
• File Type:
  [PDF - 176.36 KB ]