Manganese Is Associated with Increased Plasma Interleukin-1Β During Pregnancy, Within a Mixtures Analysis Framework of Urinary Trace Metals

Details

• Personal Author:
  Aung MT ; Bakulski KM ; Boss J ; Cantonwine DE ; Ferguson KK ; McElrath TF ; Meeker JD ; Mukherjee B
• Description:
  Exposure to trace metals may impact reproductive health outcomes through perturbations in maternal immune signaling molecules. We conducted a cross-sectional study of 390 pregnant women from the LIFECODES birth cohort and investigated the associations between 17 urinary metals and five immune biomarkers measured in the 3rd trimester (median 26 weeks gestation). We used linear regression to estimate pair-wise associations and applied elastic net and Bayesian kernel machine regression to identify important contributing exposures analytes as well as non-linear effects. Maternal urinary manganese, nickel, and barium were positively associated with maternal plasma interleukin-1β (IL-1β). Elastic net and Bayesian kernel machine regression identified manganese as the dominant trace metal in association with IL-1β. An interquartile range difference in manganese (0.6 ug/L) was associated with a 29 % increase in IL-1β (95 % CI: 12.4-48.2). In conclusion, trace metal exposures were associated with biomarkers of immune perturbations, and this warrants further investigation. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Immune System Manganese Metals Nickel Occupational Health Pregnancy Safety Urogenital System Women

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• Keywords:
  Author Keywords: Trace Metals Barium Cohort Studies Cytokines Immune Perturbations Immune System Reproductive Effects Trace Metals
• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; North Carolina ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  43-53
• Volume:
  93
• NIOSHTIC Number:
  nn:20059153
• Citation:
  Reprod Toxicol 2020 Apr; 93:43-53
• Contact Point Address:
  Kelly K. Ferguson, National Institute of Environmental Health Sciences, Epidemiology Branch, United States
• Email:
  Kelly.ferguson2@nih.gov
• CAS Registry Number:
  Barium (CAS RN 7440-39-3) ; Manganese (CAS RN 7439-96-5) ; Nickel (CAS RN 7440-02-0)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:20048fa2a08ea84ce7babe7ed6df832d6c168d513dce46037d3f16a8e8f0c76675fcd25b02d4299bd13162af246d13ae46a21ca24588a5b04e908ab91a1a7ecc
• Download URL:
  https://stacks.cdc.gov/view/cdc/223458/cdc_223458_DS1.pdf
• File Type:
  [PDF - 2.45 MB ]