Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2005.131298
Personal Author:
Buehring, Gertrude Case ; Shen, Hua Min ; Jensen, Hanne M. ; Choi, K. Yeon ; Sun, Dejun ; ... More +
Buehring, Gertrude Case ; Shen, Hua Min ; Jensen, Hanne M. ; Choi, K. Yeon ; Sun, Dejun ; Nuovo, Gerard Less -
Description:
Bovine leukemia virus (BLV), a deltaretrovirus, causes B-cell leukemia/lymphoma in cattle and is prevalent in herds globally. A previous finding of antibodies against BLV in humans led us to examine the possibility of human infection with BLV. We focused on breast tissue because, in cattle, BLV DNA and protein have been found to be more abundant in mammary epithelium than in lymphocytes. In human breast tissue specimens, we identified BLV DNA by using nested liquid-phase PCR and DNA sequencing. Variations from the bovine reference sequence were infrequent and limited to base substitutions. In situ PCR and immunohistochemical testing localized BLV to the secretory epithelium of the breast. Our finding of BLV in human tissues indicates a risk for the acquisition and proliferation of this virus in humans. Further research is needed to determine whether BLV may play a direct role in human disease.
Subject:
[+]
Animals
Base Sequence
Cattle
DNA, Viral
Female
Genes, Viral
Genome, Viral
Humans
Leukemia Virus, Bovine
Mammary Glands, Human
Molecular Sequence Data
Proviruses
Research
Sequence Alignment
Viral Core Proteins

Source:
Emerg Infect Dis. 20(5):772-782.
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:870abefad89ea5590d8aab1b067ca9e9bfc3b38a004f4e3b1ea3664e39cc5b7b
File Type:

Supporting Files

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