Non-Steroidal Anti-Inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study

Details

• Personal Author:
  Bernstein L ; Coleman AL ; Deapen D ; Heck JE ; Lee E ; Liew Z ; Marshall SF ; Pinder R ; Ritz B ; Xu X
• Description:
  Purpose: The aim of this study was to examine whether use of regular aspirin and/or other non-steroidal anti-inflammatory drugs (NSAIDs) is associated with the development of age-related macular degeneration (AMD). Methods: In the California Teachers Study cohort (N = 88,481) we identified diagnoses of AMD up to December 31, 2012 by linkage to statewide hospital discharge records. Aspirin, ibuprofen, other NSAIDs, and acetaminophen use and comprehensive risk factor information were collected via self-administered questionnaires at baseline in 1995-1996 and a follow-up questionnaire in 2005-2006. We employed Cox proportional hazard regression to model AMD risk. Results: We did not find any associations between AMD and frequency and duration of aspirin or ibuprofen use reported at baseline. In the subsample with more specific information on medication use, we observed a 20% decrease in risk of AMD among low-dose aspirin users (HR 0.81, 95% CI 0.70-0.95) and a 55% decrease among cyclooxygenase-2 (COX-2) inhibitor users (HR 0.45, 95% CI 0.26-0.78) during 6.3 years of average follow-up. Conclusion: The decrease in risk of intermediate- or late-stage AMD among women who reported regular use of low-dose aspirin or specific COX-2 inhibitors suggests a possible protective role for medications with COX-2 inhibitory properties or aspirin at doses used for cardiovascular disease prevention. [Description provided by NIOSH]
• Subjects:
  Aging Cohort Studies Drug Therapy Eye Occupational Health Safety Sense Organs Vision Disorders
• Keywords:
  Cohort Studies Drug Therapy Eye Disorders Eyesight Vision Disorders
• ISSN:
  1170-229X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  38
• Issue:
  9
• NIOSHTIC Number:
  nn:20068285
• Citation:
  Drugs Aging 2021 Sep; 38(9):817-828
• Contact Point Address:
  Julia E. Heck, College of Health and Public Service, University of North Texas, 1155 Union Circle #311340, Denton, TX, 76203-5017, USA
• Email:
  julia.heck@unt.edu
• CAS Registry Number:
  Aspirin (CAS RN 50-78-2)
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Drugs & Aging
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:172b2d616e28d23c96eef3f19f114a16ba351e30170b021c007a528f38f9cc992a78ae965bff4cf7105f75452e546b144209c775696cbaea404c19e30fce3164
• Download URL:
  https://stacks.cdc.gov/view/cdc/230465/cdc_230465_DS1.pdf
• File Type:
  [PDF - 503.23 KB ]