Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study

Details

• Personal Author:
  Bakulski K ; Hu H ; Moroi S ; Mukherjee B ; Park SK ; Schaumberg D ; Sparrow D ; Vokonas PS ; Wang W ; Weisskopf MG
• Description:
  BACKGROUND: Oxidative stress may play an important role in the etiology of primary open-angle glaucoma (POAG). The association between risk of POAG and lead exposure, which is an environmental source of oxidative stress, has not been fully investigated yet. OBJECTIVE: Our objective was to determine the association between bone lead-a biomarker of cumulative lead dose (tibia lead) or an endogenous source of stored lead (patella lead)-and incident POAG. METHODS: We examined a prospective cohort of 634 POAG-free men [mean baseline age=66.8 y of age (SD=6.7)] from the Normative Aging Study (NAS) who had tibia and patella K X-ray fluorescence lead measurements between 1 January 1991 and 31 December 1999. They also had standard ocular evaluations by NAS optometrists until 31 December 2014. POAG cases were identified by consistent reports of enlarged or asymmetric cup-to-disc ratio together with visual field defect or existence of disc hemorrhage. We used Cox proportional hazards regressions to estimate hazard ratios (HRs) of incident POAG and adjusted survival curves to examine changes in the risk of POAG during follow-up according to bone lead quartiles. RESULTS: We identified 44 incident cases of POAG by the end of follow-up (incidence rate=74 per 10,000 person-years; median follow-up=10.6 y). In fully adjusted models, 10-fold increases in patella lead and tibia lead were associated with HRs of 5.06 (95% CI: 1.61, 15.88, p=0.005) and 3.07 (95% CI: 0.94, 10.0, p=0.06), respectively. The HRs comparing participants in the third and fourth quartiles with the lowest quartile were 3.41 (95% CI: 1.34, 8.66) and 3.24 (95% CI: 1.22, 8.62) for patella lead (p-for-trend=0.01), and 3.84 (95% CI: 1.54, 9.55) and 2.61 (95% CI: 0.95, 7.21) for tibia lead (p-for-trend=0.02). CONCLUSIONS: Our study provides longitudinal evidence that bone lead may be an important risk factor for POAG in the U.S. population. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Biomarkers Cohort Studies Eye Lead Men Occupational Health Risk Assessment Risk Factors Safety Sense Organs Vision Disorders

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• Keywords:
  Age Factors Bone Structure Cohort Studies Etiology Exposure Assessment Eye Disorders Eye Hazards Eyesight Humans Lead Absorption Lead Compounds Optical Analysis Oxidative Stress Risk Factors Vision Disorders Visual Fields

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 5 ; OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  126
• Issue:
  8
• NIOSHTIC Number:
  nn:20052356
• Citation:
  Environ Health Perspect 2018 Aug; 126(8):087002
• Contact Point Address:
  S. K. Park, Department of Epidemiology and Department of Environmental Health Sciences, University of Michigan M5541 SPHII, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8415b58a2b23306731222b062197684ebb94fb11e663bc533e57181b7144547641129babe663c0c8a87355842928812d899b3bffcd4b4556a7c23d6a64f2bb19
• Download URL:
  https://stacks.cdc.gov/view/cdc/211898/cdc_211898_DS1.pdf
• File Type:
  [PDF - 768.17 KB ]