Hypertension, Antihypertensive Medications Use and Risk of Age-Related Macular Degeneration in California Teachers Cohort

Details

• Personal Author:
  Bernstein L ; Coleman A ; Deapen D ; Heck JE ; Lee E ; Liew Z ; Marshall S ; Pinder R ; Ritz B ; Xu X
• Description:
  Sustained and inadequately controlled hypertension can promote the development of age-related macular degeneration (AMD) through multiple biologic pathways. Epidemiologic studies of high blood pressure, antihypertensive therapies, and the risk of AMD thus far have been inconclusive. However, few studies evaluated risks according to the use of different classes of antihypertensive drugs or took combinations of use into account. We performed a prospective cohort study by linking the California Teachers Study (CTS) cohort (N = 88 481) to statewide hospital discharge records up to December 31, 2012. History of high blood pressure, regular use of antihypertensive medications, and comprehensive risk factor information was collected via self-administered questionnaires at baseline in 1995-1996, and information on specific classes of antihypertensive drugs was provided by a subsample of CTS participants who completed a follow-up questionnaire in 2000. We identified 1762 female teachers with AMD during 14.8 years of follow-up on average. Applying Cox proportional hazard regression, we estimated increased risks of AMD among women treated for hypertension at baseline (HR = 1.15, 95% CI: 1.03, 1.30); the magnitude of the association increased with longer duration of antihypertensive treatment. In the subsample with more specific information on type of medication use, we estimated a 45% increased risk of AMD among women receiving diuretics as monotherapy compared to women with medications more potent than diuretics (HR = 1.45, 95% CI 1.10, 1.90). In women treated with a combination of antihypertensive drugs, we observed no increased risk of AMD for any individual class of drugs. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Cohort Studies Epidemiology Eye Occupational Health Safety Sense Organs Vision Disorders
• Keywords:
  Blood Pressure Cohort Studies Eye Disorders Eyesight Hypertension Prescription Drugs Vision Disorders
• ISSN:
  0950-9240
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  34
• Issue:
  8
• NIOSHTIC Number:
  nn:20068295
• Citation:
  J Hum Hypertens 2020 Sep; 34(8):568-576
• Contact Point Address:
  Julia E. Heck, Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA, USA
• Email:
  jeheck@ucla.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Human Hypertension
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5c41844febd2e3b2fdb97e9e714bfebeb80036c7184a677b16324060447b0a05d3065543e44a14c0f76f8d45885b949ba8b40086c22d29aa4ff5b248dd6ce2c4
• Download URL:
  https://stacks.cdc.gov/view/cdc/230475/cdc_230475_DS1.pdf
• File Type:
  [PDF - 459.96 KB ]