Systemic Toxicity Induced by Topical Application of Heptafluorobutyric Acid (PFBA) in a Murine Model

Details

• Personal Author:
  Anderson, Stacey E. ; Baur R ; Lukomska E ; Shane HL ; Weatherly LM
• Description:
  Heptafluorobutyric acid (PFBA) is a synthetic chemical belonging to the per- and polyfluoroalkyl substances (PFAS) group that includes over 5000 chemicals incorporated into numerous products. PFBA is a short-chain PFAS (C4) labeled as a safer alternative to legacy PFAS which have been linked to numerous health effects. Despite the high potential for dermal exposure, occupationally and environmentally, dermal exposure studies are lacking. Using a murine model, this study analyzed serum chemistries, histology, immune phenotyping, and gene expression to evaluate the systemic toxicity of sub-chronic dermal PFBA 15-day (15% v/v or 375 mg/kg/dose) or 28-day (3.75-7.5% v/v or 93.8-187.5 mg/kg/dose) exposures. PFBA exposure produced significant increases in liver and kidney weights and altered serum chemistries (all exposure levels). Immune-cell phenotyping identified significant increases in draining lymph node B-cells (15%) and CD11b + cells (3.75-15%) and skin T-cells (3.75-15%) and neutrophils (7.5-15%). Histopathological and gene expression changes were observed in both the liver and skin after dermal PFBA exposure. The findings indicate PFBA induces liver toxicity and alterations of PPAR target genes, suggesting a role of a PPAR pathway. These results demonstrate that sustained dermal exposure to PFBA induces systemic effects and raise concerns of short-chain PFAS being promoted as safer alternatives. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Exposure Hazardous Substances Occupational Exposure Occupational Health Safety Skin Textile Industry
• Keywords:
  Animal Studies Author Keywords: PFBA Dermal Dermal Exposures Environmental Exposure Heptafluorobutyric Acid Liver Toxicity Occupational Exposure Per- And Polyfluoroalkyl Substances PFAS Skin Exposure Synthetic Materials Textiles Toxic Effects Toxicity

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• ISSN:
  0278-6915
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  156
• NIOSHTIC Number:
  nn:20063484
• Citation:
  Food Chem Toxicol 2021 Oct; 156:112528
• Contact Point Address:
  Lisa M. Weatherly, National Institute for Occupational Safety and Health (NIOSH), 1000 Fredrick Lane, Morgantown, WV 26505
• Email:
  nux6@cdc.gov
• CAS Registry Number:
  Heptafluorobutyric acid (CAS RN 375-22-4)
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Healthcare and Social Assistance ; Oil and Gas Extraction
• Peer Reviewed:
  True
• Source Full Name:
  Food and Chemical Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bce206ff1a49730107ddc04ad6c542917be067515a3dd1c3f22afb52396b64395ec504b3fd2b10d146d1feca45597d5805269efc0b9808e5f827c5ce531699ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/226541/cdc_226541_DS1.pdf
• File Type:
  [PDF - 5.39 MB ]