Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model (dataset).

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Heptafluorobutyric acid (PFBA) is a synthetic chemical belonging to the per- and polyfluoroalkyl substances (PFAS) group that includes over 5,000 chemicals. PFBA is a short-chain PFAS (C4) that has been labeled as a safer alternative to the legacy PFAS perfluorooctanoic acid (PFOA) and perfluorooctane sulfate (PFOS) which have been linked to numerous health effects. This class of chemicals are incorporated into consumer products such as stain resistant carpeting and textiles, nanosprays, medical devices, and fire-fighting foams. There is a high potential for occupational exposure and in the environment, PFBA has been detected in a variety of water sources leading to concerns for dermal exposure, however, these studies are lacking. In previous studies from our lab, PFOA was demonstrated to be absorbed via the skin and immunomodulatory. In the present study, the systemic toxicity of a 28-day dermal PFBA (3.75-15% w/v, or 93.8-375 mg/kg/dose) exposure was evaluated in a murine model. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Exposure Occupational Exposure Occupational Health Safety Skin Textile Industry
• Keywords:
  Dermal exposures; Skin exposure; Synthetic materials; Occupational exposure; Environmental exposure; Animal studies; Textiles; Per- and polyfluoroalkyl substances; PFAS; Toxic effects
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20064897
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1033-2022-0, 2022 Apr; :dataset
• Contact Point Address:
  Allergy and Clinical Immunology Branch (ACIB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV. Phone: 304.285.6024
• CAS Registry Number:
  Heptafluorobutyric acid (CAS RN 375-22-4)
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Healthcare and Social Assistance ; Oil and Gas Extraction
• Peer Reviewed:
  False
• Source Full Name:
  Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ce143284805e64581085108a351a7e0168090fb612cb11f92461ecc44303e301ba4246df7d9b4f29a67f86beba0f9363e999831f01a5a723a3118aa4bd4401f2
• Download URL:
  https://stacks.cdc.gov/view/cdc/249268/cdc_249268_DS1.pdf
• File Type:
  [PDF - 175.32 KB ]