Outcome Risk Factors during Respiratory Infections in a Paediatric Ward in Antananarivo, Madagascar 2010–2012

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Rajatonirina, Soatiana ; Razanajatovo, Norosoa Harline ; Ratsima, Elisoa Hariniana ; Orelle, Arnaud ; Ratovoson, Rila ; Andrianirina, Zo Zafitsara ; Andriatahina, Todisoa ; Ramparany, Lovasoa ; Herindrainy, Perlinot ; Randrianirina, Frédérique ; Heraud, Jean-Michel ; Richard, Vincent
• Description:
  Background
  
  Acute respiratory infections are a leading cause of infectious disease-related morbidity, hospitalisation and mortality among children worldwide, and particularly in developing countries. In these low-income countries, most patients with acute respiratory infection (ARI), whether it is mild or severe, are still treated empirically.
  
  Materials and Methods
  
  We conducted a prospective study in a paediatric ward in Antananarivo from November 2010 to July 2012 including patients under 5 years old suffering from respiratory infections. We collected demographic, socio-economic, clinical and epidemiological data, and samples for laboratory analysis. Deaths, rapid progression to respiratory distress during hospitalisation, and hospitalisation for more than 10 days were considered as severe outcomes. We used multivariate analysis to study the effects of co-infections.
  
  Results
  
  From November 2010 to July 2012, a total of 290 patients were enrolled. Co-infection was found in 192 patients (70%). Co-infections were more frequent in children under 36 months, with a significant difference for the 19–24 month-old group (OR: 8.0).
  
  Conclusion
  
  Co-mordidity, low-income and age under 6 months increase the risk of severe outcome for children infected by numerous respiratory pathogens. These results highlight the need for implementation of targeted public health policy to reduce the contribution of respiratory diseases to childhood morbidity and mortality in low income countries.
  
  
• Subjects:
  Child, Preschool Female Hospitals Humans Infant Male Pediatrics Prospective Studies Respiratory Tract Infections Risk Factors
• Source:
  PLoS One. 2013; 8(9).
• Pubmed ID:
  24069161
• Pubmed Central ID:
  PMC3771918
• Document Type:
  Journal Article
• Funding:
  U51/IP000327-02/IP/NCIRD CDC HHS/United States
• Place as Subject:
  Madagascar
• Volume:
  8
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c9cedecfd74b6e51c370ec5a70fa0dc5d6af5fd7aff9619fdea1d4c2b16d4a28
• Download URL:
  https://stacks.cdc.gov/view/cdc/22572/cdc_22572_DS1.pdf
• File Type:
  [PDF - 893.38 KB ]