Some Effects of D-Amphetamine, Caffeine, Nicotine and Cocaine on Schedule-Controlled Responding of the Mouse

Details

• Personal Author:
  Glowa JR
• Description:
  The effects of d-amphetamine (0.03-10.0 mg/kg), caffeine (0.3-100.0 mg/kg), nicotine (0.003-10.0 mg/kg) and cocaine (0.03-56.0 mg/kg) were compared on responding maintained under three different schedules of food presentation in mice. Cumulative doses of d-amphetamine, nicotine and cocaine only decreased responding maintained under fixed-ratio 30 response, fixed-interval 60-sec and fixed-interval 60-sec schedules with a punishment contingency (suppressed responding). In most cases there was an inverse relationship between the ED50 (dose which decreased responding by 50%) for the drug and the rate of responding maintained under each schedule. The exceptions were, (i) with both d-amphetamine and cocaine the ED50 for suppressed responding was smaller than that for non-suppressed fixed-interval responding, and (ii) with nicotine the ED50 for fixed-ratio responding was smaller than that for fixed-interval responding. In contrast, intermediate doses of caffeine increased suppressed responding, had little effect on fixed-interval responding and decreased fixed-ratio responding. This difference in profile of effect over the range of conditions studied, suggests that the behavioral effects of psychomotor stimulants can be used to examine potential differences in the mechanisms of action of each drug. Such findings may aid in the understanding of the relationships between the neuropharmacological and behavioral effects of psychomotor stimulant drugs. [Description provided by NIOSH]
• Subjects:
  Amphetamine Animals Nicotine Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: D-amphetamine Caffeine Cocaine Dose Response Fixed-interval Fixed-ratio Mice Neurological Reactions Pharmacology Schedule-controlled Behavior Stimulants Suppressed Responding

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• ISSN:
  0028-3908
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• Issue:
  10
• NIOSHTIC Number:
  nn:20060277
• Citation:
  Neuropharmacology 1987 Oct; 25(10):1127-1135
• CAS Registry Number:
  (-)-Nicotine (CAS RN 54-11-5) ; Amphetamine (CAS RN 300-62-9) ; Caffeine (CAS RN 58-08-2) ; Cocaine (CAS RN 50-36-2)
• Federal Fiscal Year:
  1988
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19780501
• Source Full Name:
  Neuropharmacology
• End Date:
  19840430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bedf494a560135e531ace3566831e4f3410e99f24bdb750e387cdd5401c60b05d4eed51642557891068f27bfdeb4b20e3288969b71c49c105ea9943bff158685
• Download URL:
  https://stacks.cdc.gov/view/cdc/224228/cdc_224228_DS1.pdf
• File Type:
  [PDF - 578.11 KB ]