Exposure of Mice to Tobacco Smoke Attenuates the Toxic Effect of Methamphetamine on Dopamine Systems

Details

• Personal Author:
  Ali SF ; Bondy SC ; Kleinman MT
• Description:
  Methamphetamine treatment of mice rapidly and severely depleted levels of dopamine and its metabolites, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) in the caudate nucleus. Exposure of mice to cigarette smoke by means of nose-only breathing apparatus for 20 min twice daily over 3 days prior to drug treatment significantly attenuated the neurotoxicity of methamphetamine as judged by a lesser depletion of dopamine, DOPAC and HVA. The lesser effect of methamphetamine upon content of serotonin level was unaltered by prior inhalation of smoke. Results suggest a specific protective effect of inhaled tobacco smoke upon the effects of methamphetamine upon dopaminergic circuitry. [Description provided by NIOSH]
• Subjects:
  Animals Nervous System Nicotine Occupational Health Safety Smoke Tobacco Products
• Keywords:
  Animal Studies Author Keywords: Tobacco Smoke Cigarettes Cigarette Smoke Dopamine Methamphetamine Neurotoxic Effects Neurotoxicity Parkinson's Disease Tobacco Smoke
• ISSN:
  0378-4274
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; California ; OSHA Region 6 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  43-46
• Volume:
  118
• Issue:
  1
• NIOSHTIC Number:
  nn:20058042
• Citation:
  Toxicol Lett 2000 Dec; 118(1-2):43-46
• Contact Point Address:
  Stephen C Bondy, Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697-1820, USA
• Email:
  scbondy@uci.edu
• Federal Fiscal Year:
  2001
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  Toxicology Letters
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b44367c5e9e5a87082724004e119f72b59a91c5bf6058651608f7760f6915fde27e48d7ebc8c0801246422bd06e7c3af7001b6f9101c8358fd30660ead475e0d
• Download URL:
  https://stacks.cdc.gov/view/cdc/221233/cdc_221233_DS1.pdf
• File Type:
  [PDF - 130.47 KB ]