Differential Effects of Amphetamine and Related Compounds on Locomotor Activity and Metabolic Rate in Mice

Details

• Personal Author:
  Bushnell PJ
• Description:
  Locomotor activity was measured by photobeam interruptions, and metabolic rate by the production of CO2 (as minute volume expired CO2, or VECO2) in mice. d-Amphetamine (0.3 to 10 mg/kg IP) increased locomotor activity in a dose-dependent manner while suppressing VECO2 over the same 72-min test period, compared to saline-injected controls. This phenomenon of divergent effects on locomotor activity and metabolic rate required central stimulation, as neither ammonium sulfate nor p-hydroxyamphetamine suppressed VECO2. Oxygen consumption was also suppressed by d-amphetamine, indicating that the suppression of VECO2 involved more than a change in respiratory quotient. When baseline activity rates were increased with running wheels, VECO2 and activity were both suppressed by d-amphetamine more in exercising mice than in sedentary mice. Anorexigenic agents phenmetrazien, animoxaphen, and fenfluramine, when administered in doses equimolar to maximally effective doses of d-amphetamine, did not consistently affect activity or VECO2. Evidence for mediation of the VECO2 response by corticosterone and endogenous opioid peptides was negative. Further work, with other mediators of the stress response, or with more complete dose-effect studies with anorexigenic compounds, may be necessary to explicate the mechanism of this counter-intuitive divergence of two measures of activity in mice. Description provided by NIOSH
• Subjects:
  • Amphetamine
  • Animals
  • Biochemistry
  • Energy Metabolism
  • Occupational Health
  • Safety
• Keywords:
  • Amphetamine
  • Dose response
  • Animal studies
  • Motion studies
  • Metabolic rate
  • Metabolic effects
  • Pharmacology
  • Biochemistry
  • Author Keywords: d-Amphetamine
  • Aminoxaphen
  More +
• ISSN:
  0091-3057
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; North Carolina ; OSHA Region 2 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  161-170
• Volume:
  25
• Issue:
  1
• NIOSHTIC Number:
  nn:20060308
• Citation:
  Pharmacol Biochem Behav 1986 Jul; 25(1):161-170
• Contact Point Address:
  Philip J. Bushnell, U.S. Environmental Protection Agency, Neurotoxicology Division (MD-74B), Research Triangle Park, NC 27711, USA
• CAS Registry Number:
  • Amphetamine (CAS RN 300-62-9)
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  True
• Source Full Name:
  Pharmacology Biochemistry and Behavior
• Download URL:
  https://stacks.cdc.gov/view/cdc/224253/cdc_224253_DS1.pdf
• File Type:
  [PDF - 332.13 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b2785074df9426fd4b4561a861be0f3035498fa121c112aff114bcd03ade0e37bf04c77af11b0e9d2806c4adc492fc65e8644493ec646c03fa0fd246d549e5ee