Interleukin (IL)-33 Immunobiology in Asthma and Airway Inflammatory Diseases

Details

• Personal Author:
  Gaurav R ; Poole JA
• Description:
  Objective: Identify key features of IL-33 immunobiology important in allergic and nonallergic airway inflammatory diseases and potential therapeutic strategies to reduce disease burden. Data Sources: PubMed, clinicaltrials.gov Study Selections: A systematic and focused literature search was conducted of PubMed from March 2021 to December 2021 using keywords to either PubMed or BioMed Explorer including IL-33/ST2, genetic polymorphisms, transcription, translation, post-translation modification, nuclear protein, allergy, asthma, and lung disease. Clinical trial information on IL-33 was extracted from clinicaltrials.gov in August 2021. Results: In total, 72 publications with relevance to IL-33 immunobiology and/or clinical lung disease were identified (allergic airway inflammation/allergic asthma n = 26, non-allergic airway inflammation n = 9, COPD n = 8, lung fibrosis n = 10). IL-33 levels were higher in serum, BALF and/or lungs across inflammatory lung diseases. Eight studies described viral infections and IL-33 and 4 studies related to COVID-19. Mechanistic studies (n = 39) including transcript variants and post-translational modifications related to the immunobiology of IL-33. Single nucleotide polymorphism in IL-33 or ST2 were described in 9 studies (asthma n = 5, inflammatory bowel disease n = 1, mycosis fungoides n = 1, ankylosing spondylitis n = 1, coronary artery disease n = 1). Clinicaltrials.gov search yielded 84 studies of which 17 were related to therapeutic or biomarker relevance in lung disease. Conclusion: An integral role of IL-33 in the pathogenesis of allergic and nonallergic airway inflammatory disease is evident with several emerging clinical trials investigating therapeutic approaches. Current data support a critical role of IL-33 in damage signaling, repair and regeneration of lungs. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Biomarkers Communicable Diseases Genetics Hypersensitivity Immune System Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety

  More +
• Keywords:
  Allergic Asthma Allergic Reactions Allergies Asthma-COPD Overlap Author Keywords: IL-33 COVID-19 Genes Genetic Factors Immune Reaction Immunology Lung Disease Lung Fibrosis Non-allergic Asthma Regeneration Repair Respiratory Diseases

  More +
• ISSN:
  0277-0903
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  12
• NIOSHTIC Number:
  nn:20064597
• Citation:
  J Asthma 2022 Dec; 59(12):2530-2538
• Contact Point Address:
  Rohit Gaurav, Department of Internal Medicine, Division of Allergy and Immunology, 985910 Nebraska Medical Center, Omaha, NE 68198-5910, USA
• Email:
  rohit.gaurav@unmc.edu
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Journal of Asthma
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:da0f07312ca67599b1545f09d47201006f96c7314f8fa9e24423de23c32ea282cb90ff6e91f5c8f135ae4d97aa1b9beb83fbb37fcea77d5881cfa31dc4c28b68
• Download URL:
  https://stacks.cdc.gov/view/cdc/223032/cdc_223032_DS1.pdf
• File Type:
  [PDF - 1.13 MB ]