Interleukin (IL)-33 Immunobiology in Asthma and Airway Inflammatory Diseases

Details

• Alternative Title:
  J Asthma
• Personal Author:
  Gaurav, Rohit ; Poole, Jill A.
• Description:
  Objective:
  
  Identify key features of IL-33 immunobiology important in allergic and nonallergic airway inflammatory diseases and potential therapeutic strategies to reduce disease burden.
  
  Data Sources:
  
  PubMed, clinicaltrials.gov
  
  Study Selections:
  
  A systematic and focused literature search was conducted of PubMed from March 2021 to December 2021 using keywords to either PubMed or BioMed Explorer including IL-33/ST2, genetic polymorphisms, transcription, translation, post-translation modification, nuclear protein, allergy, asthma, and lung disease. Clinical trial information on IL-33 was extracted from clinicaltrials.gov in August 2021.
  
  Results:
  
  In total, 72 publications with relevance to IL-33 immunobiology and/or clinical lung disease were identified (allergic airway inflammation/allergic asthma n = 26, non-allergic airway inflammation n = 9, COPD n = 8, lung fibrosis n = 10). IL-33 levels were higher in serum, BALF and/or lungs across inflammatory lung diseases. Eight studies described viral infections and IL-33 and 4 studies related to COVID-19. Mechanistic studies (n = 39) including transcript variants and post-translational modifications related to the immunobiology of IL-33. Single nucleotide polymorphism in IL-33 or ST2 were described in 9 studies (asthma n = 5, inflammatory bowel disease n = 1, mycosis fungoides n = 1, ankylosing spondylitis n = 1, coronary artery disease n = 1). Clinicaltrials.gov search yielded 84 studies of which 17 were related to therapeutic or biomarker relevance in lung disease.
  
  Conclusion:
  
  An integral role of IL-33 in the pathogenesis of allergic and nonallergic airway inflammatory disease is evident with several emerging clinical trials investigating therapeutic approaches. Current data support a critical role of IL-33 in damage signaling, repair and regeneration of lungs.
  
  
• Keywords:
  Allergic Asthma Asthma Asthma-COPD Overlap COVID-19 Humans Hypersensitivity IL-33 Inflammation Interleukin-1 Receptor-Like 1 Protein Interleukin-33 Lung Lung Fibrosis Non-allergic Asthma Regeneration Repair

  More +
• Source:
  J Asthma. 59(12):2530-2538
• Pubmed ID:
  34928757
• Pubmed Central ID:
  PMC9234100
• Document Type:
  Journal Article
• Funding:
  R01 ES019325/ES/NIEHS NIH HHSUnited States/ ; R01 OH012045/OH/NIOSH CDC HHSUnited States/ ; U54 OH010162/OH/NIOSH CDC HHSUnited States/ ; U54OH010162/ACL/ACL HHSUnited States/
• Volume:
  59
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:714e428c3ea235a6aeec27a2c7173cf7ff15010ee0afd682b4723097452294da
• Download URL:
  https://stacks.cdc.gov/view/cdc/118653/cdc_118653_DS1.pdf
• File Type:
  [PDF - 466.86 KB ]