Polygenic Risk Scores for Asthma and Allergic Disease Associate with COVID-19 Severity in 9/11 Responders

Details

• Personal Author:
  Carr MA ; Clouston SAP ; Docherty AR ; Kotov R ; Lhuillier E ; Luft BJ ; Morozova O ; Shabalin AA ; Waszczuk MA ; Yang X
• Description:
  Background: Genetic factors contribute to individual differences in the severity of coronavirus disease 2019 (COVID-19). A portion of genetic predisposition can be captured using polygenic risk scores (PRS). Relatively little is known about the associations between PRS and COVID-19 severity or post-acute COVID-19 in community-dwelling individuals. Methods: Participants in this study were 983 World Trade Center responders infected for the first time with SARS-CoV-2 (mean age at infection = 56.06; 93.4% male; 82.7% European ancestry). Seventy-five (7.6%) responders were in the severe COVID-19 category; 306 (31.1%) reported at least one post-acute COVID-19 symptom at 4-week follow-up. Analyses were adjusted for population stratification and demographic covariates. Findings: The asthma PRS was associated with severe COVID-19 category (odds ratio [OR] = 1.61, 95% confidence interval: 1.17-2.21) and more severe COVID-19 symptomatology (β = .09, p = .01), independently of respiratory disease diagnosis. Severe COVID-19 category was also associated with the allergic disease PRS (OR = 1.97, [1.26-3.07]) and the PRS for COVID-19 hospitalization (OR = 1.35, [1.01-1.82]). PRS for coronary artery disease and type II diabetes were not associated with COVID-19 severity. Conclusion: Recently developed polygenic biomarkers for asthma, allergic disease, and COVID-19 hospitalization capture some of the individual differences in severity and clinical course of COVID-19 illness in a community population. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Biomarkers Communicable Diseases Emergency Responders Hypersensitivity Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Allergic Reactions COVID-19 First Responders Genetic Factors SARS-CoV-2 World Trade Center WTC
• ISSN:
  1932-6203
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; New York ; OSHA Region 2 ; OSHA Region 5 ; OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  3
• NIOSHTIC Number:
  nn:20067615
• Citation:
  PLoS One 2023 Mar; 18(3):e0282271
• Email:
  benjamin.luft@stonybrookmedicine.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  State University of New York at Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20210701
• Source Full Name:
  PLoS One
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:afea6b5a11b42ff1a8eb2931a1ec33a88e5e52d03ed4fac19165686a363da01b975c0e840b843a77d92c98c8c184933a0d6e68e7d19e127913342ba1de78bf6b
• Download URL:
  https://stacks.cdc.gov/view/cdc/231508/cdc_231508_DS1.pdf
• File Type:
  [PDF - 419.19 KB ]