Indirect Mediators of Systemic Health Outcomes Following Nanoparticle Inhalation Exposure

Details

• Personal Author:
  Campen MJ ; Canal CG ; Cho M ; Erdely A ; Mostovenko E ; Ottens AK ; Sharma K
• Description:
  The growing field of nanoscience has shed light on the wide diversity of natural and anthropogenic sources of nano-scale particulates, raising concern as to their impacts on human health. Inhalation is the most robust route of entry, with nanoparticles (NPs) evading mucociliary clearance and depositing deep into the alveolar region. Yet, impacts from inhaled NPs are evident far outside the lung, particularly on the cardiovascular system and highly vascularized organs like the brain. Peripheral effects are partly explained by the translocation of some NPs from the lung into the circulation; however, other NPs largely confined to the lung are still accompanied by systemic outcomes. Omic research has only just begun to inform on the complex myriad of molecules released from the lung to the blood as byproducts of pulmonary pathology. These indirect mediators are diverse in their molecular make-up and activity in the periphery. The present review examines systemic outcomes attributed to pulmonary NP exposure and what is known about indirect pathological mediators released from the lung into the circulation. Further focus was directed to outcomes in the brain, a highly vascularized region susceptible to acute and longer-term outcomes. Findings here support the need for big-data toxicological studies to understand what drives these health outcomes and better predict, circumvent, and treat the potential health impacts arising from NP exposure scenarios. [Description provided by NIOSH]
• Subjects:
  Blood Environmental Exposure Inhalation Exposure Lung Nervous System Occupational Health Pathology Respiratory System Risk Assessment Risk Factors Safety

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• Keywords:
  Alveolar Cells Author Keywords: Inhalation Toxicology Brain Function Cardiovascular System Exposure Levels Health Effects Inhalants Inhalation Molecular Structure Nanomaterials Nanoparticles Nanotechnology Nanotubes Neurotoxicology Peptidomics Pulmonary System Risk Factors

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• ISSN:
  0163-7258
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Mexico ; OSHA Region 3 ; OSHA Region 6 ; Virginia ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  235
• NIOSHTIC Number:
  nn:20064559
• Citation:
  Pharmacol Ther 2022 Jul; 235:108120
• Contact Point Address:
  Andrew K. Ottens, Department of Anatomy and Neurobiology, Virginia Commonwealth University, PO Box 980709, Richmond, VA 23298, USA
• Email:
  akottens@vcu.edu
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of New Mexico Health Sciences Center, Albuquerque, New Mexico
• Peer Reviewed:
  True
• Start Date:
  20130901
• Source Full Name:
  Pharmacology & Therapeutics
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bb38948bab690dbc93f8cacd29fecc3fd2cad4f3e6e59164d546e45782332f9bd6af6886520c206cd354f8412cfe8212c3a6a629cd7c91659782c3a6dfc8cf3f
• Download URL:
  https://stacks.cdc.gov/view/cdc/222999/cdc_222999_DS1.pdf
• File Type:
  [PDF - 2.01 MB ]