Per- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition

Details

• Personal Author:
  Calafat, Antonia M. ; Ding N ; Gold EB ; Harlow SD ; Hood MM ; Mukherjee B ; Park SK ; Randolph JF Jr.
• Description:
  Context: Per- and polyfluoroalkyl substances (PFAS) are widespread chemicals that may affect sex hormones and accelerate reproductive aging in midlife women. Objective: To examine associations between serum PFAS concentrations at baseline (1999- 2000) and longitudinal serum concentrations of follicle-stimulating hormone (FSH), estradiol, testosterone, and sex hormone-binding globulin (SHBG) at baseline and through 2015-2016. Design: Prospective cohort. Setting: General community. Participants: 1371 midlife women 45 to 56 years of age at baseline in the Study of Women's Health Across the Nation (SWAN). Main Outcome Measure(s): FSH, estradiol, testosterone, SHBG. Results: In linear mixed models fitted with log-transformed hormones and log-transformed PFAS adjusting for age, site, race/ethnicity, smoking status, menopausal status, parity, and body mass index, FSH was positively associated with linear perfluorooctanoate [n-PFOA; 3.12% (95% CI 0.37%, 5.95%) increase for a doubling in serum concentration), linear perfluorooctane sulfonate [PFOS; 2.88% (0.21%, 5.63%)], branched perfluorooctane sulfonate [2.25% (0.02%, 4.54%)], total PFOS (3.03% (0.37%, 5.76%)), and 2-(N-ethyl-perfluorooctane sulfonamido) acetate [EtFOSAA; 1.70% (0.01%, 3.42%)]. Estradiol was inversely associated with perfluorononanoate [PFNA; -2.47% (-4.82%, -0.05%)) and n-PFOA (-2.43% (-4.97%, 0.18%)]. Significant linear trends were observed in the associations between PFOS and EtFOSAA with SHBG across parity (Ps trend ≤ 0.01), with generally inverse associations among nulliparous women but positive associations among women with 3+ births. No significant associations were observed between PFAS and testosterone. Conclusions: This study observed positive associations of PFOA and PFOS with FSH and inverse associations of PFNA and PFOA with estradiol in midlife women during the menopausal transition, consistent with findings that PFAS affect reproductive aging. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Endocrine System Occupational Health Race Factors Safety Smokers Urogenital System Women
• Keywords:
  Author Keywords: PFAS BMI Body Mass Index Cohort Studies Hormone Activity Hormones Longitudinal Study Long Term Study Menopausal Transition Parity Per- And Polyfluoroalkyl Substances PFAS Racial Factors Reproductive System Sex Hormones Smoking

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• ISSN:
  0021-972X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; Michigan ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  106
• Issue:
  11
• NIOSHTIC Number:
  nn:20064202
• Citation:
  J Clin Endocrinol Metab 2021 Nov; 106(11):e4427-e4437
• Contact Point Address:
  Sung Kyun Park, ScD, MPH, Departments of Epidemiology and Environmental Health Sciences, University of Michigan, School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109-2029
• Email:
  sungkyun@umich.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Clinical Endocrinology and Metabolism
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9ca3bb5fc142e0ceff560e10a5cbf06dcb7e33ab3540c01e873c24654b5d837909f2fc5d783beb947091a305e44059bd7c85a9ce649301088df12ad12a5b8ae0
• Download URL:
  https://stacks.cdc.gov/view/cdc/222707/cdc_222707_DS1.pdf
• File Type:
  [PDF - 217.78 KB ]