Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation

Details

• Personal Author:
  Batterman S ; Calafat, Antonia M. ; Ding N ; Gold EB ; Harlow SD ; Mukherjee B ; Park SK ; Randolph JF Jr.
• Description:
  Context: Previous epidemiologic studies of per- and polyfluoroalkyl substances (PFASs) and menopausal timing conducted in cross-sectional settings were limited by reverse causation because PFAS serum concentrations increase after menopause. Objectives: To investigate associations between perfluoroalkyl substances and incident natural menopause. Design and Setting: A prospective cohort of midlife women, the Study of Women's Health Across the Nation, 1999-2017. Participants: 1120 multiracial/ethnic premenopausal women aged 45-56 years. Methods: Serum concentrations of perfluoroalkyls were quantified by high-performance liquid chromatography isotope dilution tandem mass spectrometry. Natural menopause was defined as the bleeding episode prior to at least 12 months of amenorrhea not due to surgery or hormone use. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Participants contributed 5466 person-years of follow-up, and 578 had incident natural menopause. Compared with the lowest tertile, women at the highest tertile of baseline serum concentrations had adjusted HR for natural menopause of 1.26 (95% CI: 1.02-1.57) for n-perfluorooctane sulfonic acid (n-PFOS) (Ptrend = .03), 1.27 (95% CI: 1.01-1.59) for branched-PFOS (Ptrend = .03), and 1.31 (95% CI: 1.04-1.65) for n-perfluorooctanoic acid (Ptrend = .01). Women were classified into four clusters based on their overall PFAS concentrations as mixtures: low, low-medium, medium-high, and high. Compared with the low cluster, the high cluster had a HR of 1.63 (95% CI: 1.08-2.45), which is equivalent to 2.0 years earlier median time to natural menopause. Conclusion: This study suggests that select PFAS serum concentrations are associated with earlier natural menopause, a risk factor for adverse health outcomes in later life. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Endocrine System Occupational Health Safety Urogenital System Women
• Keywords:
  Author Keywords: Per- And Polyfluoroalkyl Substances Chemicals Cohort Studies Endocrine-disrupting Chemicals Endocrine Disruptors Endocrinology Hormone Activity Hormones Longitudinal Study Midlife Women Natural Menopause Per- And Polyfluoroalkyl Substances PFAS Reproductive System

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• ISSN:
  0021-972X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; Michigan ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  105
• Issue:
  9
• NIOSHTIC Number:
  nn:20061581
• Citation:
  J Clin Endocrinol Metab 2020 Sep; 105(9):e3169-e3182
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology, University of Michigan, M5541 SPH II, 1415 Washington Heights, Ann Arbor, MI 48109- 2029
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Perfluorocarbons (CAS RN 308069-13-8)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Clinical Endocrinology and Metabolism
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bf9198de44ae372133ba1855fa5dd733bf96bcf92bf8e5e03ef3c76c6849ebb8e88ddaba0c96a5dbdc9ccd43c229a68ce3059bdfa3f7b7a8f96b003f02f68936
• Download URL:
  https://stacks.cdc.gov/view/cdc/225084/cdc_225084_DS1.pdf
• File Type:
  [PDF - 806.83 KB ]