Potentiation of Adverse Pregnancy Outcomes Among Obese Women Exposed to Environmental Air Particulate Pollutants (PM2.5 Variant)

Details

• Personal Author:
  August E ; Mbah A ; Salihu H ; Weldeselasse H ; Whiteman V
• Description:
  Objective: We investigated whether the effects of ambient air particulate pollutants (PM2.5 variant) on birth outcomes are aggravated by maternal obesity. Study Design: This retrospective cohort study utilized data from 2004 through 2007 based on three longitudinally linked databases: (1) Florida Hospital Discharge database; (2) Vital statistics records of singleton live births in Florida; and (3) Air pollution and meteorological data from the Environmental Protection Agency (EPA). Using computerized mathematical modeling, we assigned exposure values of PM2.5 (ambient particles 2.5 micrometers in diameter and smaller) to mothers over the period of pregnancy based on Euclidean minimum distance from the air pollution monitoring sites. The primary outcomes of interest were preterm birth (moderate, severe and extreme) and infant macrosomia. We also examined the variance in outcomes by maternal pre-pregnancy obesity status. We generated adjusted odds ratios (AOR) and confidence intervals (CI) with correction for intracluster correlation using the generalized estimating equation (GEE). Results: Exposure to PM2.5 above-median population values was associated with increased risk for preterm birth among both obese (BMI>30) and non-obese mothers (BMI <30) [Table]. Regardless of the severity of the preterm, the effects of PM2.5 were more pronounced among obese mothers, with the worst potentiation of risk noted for extremely preterm birth (AOR=2.89; 95% CI=2.43-3.45). Risk elevation for macrosomia as a result of exposure to PM2.5 was only observed among infants of obese mothers (AOR=1.05; 95% CI=1.03-1.07). Conclusion: Maternal obesity widens the risk for preterm (especially, extremely preterm) birth and infant macrosomia resulting from exposure to PM2.5. These new findings identify obese mothers as a high-risk group particularly vulnerable to the adverse effects of PM2.5 pollutants. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Cohort Studies Database Environmental Exposure Occupational Health Particulate Matter Pregnancy Risk Assessment Risk Factors Safety Women

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• Keywords:
  Airborne Particulates Cohort Studies Databases Environmental Exposure Exposure Levels Humans Mathematical Models Obesity Particle Size Pollutants Prenatal Exposure Risk Factors Weight Factors

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• ISSN:
  0002-9378
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Florida ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  206
• NIOSHTIC Number:
  nn:20063688
• Citation:
  Am J Obstet Gynecol 2012 Jan; 206(Suppl 1):S253
• Federal Fiscal Year:
  2012
• Performing Organization:
  Sunshine Education and Research Center, University of South Florida
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  American Journal of Obstetrics and Gynecology
• Supplement:
  1
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:39484f466b60e75aa5fdb9d28a831a044efb68586d0b55e579b753fa140243d8ad82aae5fb4281d92e4053bb8ef313aba386bb6879d03a51990e88df866e5f8d
• Download URL:
  https://stacks.cdc.gov/view/cdc/222249/cdc_222249_DS1.pdf
• File Type:
  [PDF - 323.12 KB ]