Brief report: plasma concentrations of perfluorooctane sulfonamide and time-to-pregnancy among primiparous women.

Details

• Personal Author:
  Eggesbo M ; Haug LS ; Longnecker MP ; Sabaredzovic A ; Whitworth KW
• Description:
  Background: A previous study reported a negative association between perfluorooctane sulfonamide (PFOSA) concentrations and fecundability. Methods: We examined this association among women enrolled in the Norwegian Mother and Child Cohort Study (MoBa), in 2003-2004. This analysis was restricted to 451 primiparous women to avoid bias due to previous pregnancy. Self-reported time-to-pregnancy (TTP) and plasma were obtained around 18 weeks of gestation. Approximately half of the women had measurable PFOSA levels; missing values were multiply imputed. We used the logistic analogue of discrete-time survival analysis to examine the adjusted association between PFOSA, other perfluoroalkyl substances, and TTP. Results: The median-measured PFOSA concentration was 0.03 ng/ml (interquartile range = 0.02, 0.07). The age and body mass index-adjusted association between an interquartile distance increase in PFOSA and TTP was 0.91 (95% confidence interval = 0.71, 1.17). Imputation of missing PFOSA resulted in similar estimates. No association was observed with other perfluoroalkyl substances. Conclusion: Based on a weakly decreased fecundability odds ratio, we found only limited support for an association between plasma PFOSA concentrations and TTP among primiparous women. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Environmental Exposure Fluorocarbons Occupational Health Pregnancy Safety Women
• Keywords:
  Women; Cohort studies; Organic chemicals; Fluorocarbons; Environmental exposure; Prenatal exposure; Pregnancy; Sulfonamides
• ISSN:
  1044-3983
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  27
• Issue:
  5
• NIOSHTIC Number:
  nn:20064890
• Citation:
  Epidemiology 2016 Sep; 27(5):712-715
• Contact Point Address:
  Kristina Walker Whitworth, The University of Texas School of Public Health, San Antonio Regional Campus, 7411 John Smith Drive, Suite 1100, San Antonio, TX 78216
• Email:
  Kristina.W.Whitworth@uth.tmc.edu
• CAS Registry Number:
  Perfluorooctanesulfonamide (CAS RN 754-91-6)
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b6825397197a349e2f0b9c402d55c07e7099d8d78a3957084d20f4c0b4d40ca5fa3e19cc108228a6b4cfbd7198c431b5d78bb564b805ea43e2b747d583227b85
• Download URL:
  https://stacks.cdc.gov/view/cdc/248763/cdc_248763_DS1.pdf
• File Type:
  [PDF - 180.13 KB ]