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The Impact of Repeated Organophosphorus Pesticide Exposure on Biomarkers and Neurobehavioral Outcomes Among Adolescent Pesticide Applicators



Details

  • Personal Author:
  • Description:
    Egyptian adolescents are hired as seasonal workers to apply pesticides to the cotton crop and may perform this occupation for several years. However, few studies examined the effects of repeated pesticide exposure on health outcomes The goal of this study was to determine the impact of repeated pesticide exposure on neurobehavioral (NB) performance and biomarkers of exposure (urinary metabolite) and effect (cholinesterase activity). Eighty-four adolescents from two field stations in Menoufia, Egypt, were examined four times: before and during pesticide application season in 2010 and again before and during application season in 2011. At each of the four time points, participants completed a questionnaire, performed an NB test battery, and were assessed for urinary levels of the chlorpyrifos metabolite TCPy (3,5,6-trichloro-2-pyridinol) and blood cholinesterase activity. Following the study cohort over two consecutive pesticide application seasons revealed that TCPy levels significantly increased following exposure, and returned to baseline levels following the end of the application season. Blood butyryl cholinesterase activity exhibited a similar pattern. Although NB outcomes displayed learning and practice effects over time, deficits in performance were significantly associated with increased TCPy levels with reduction in the number of NB measures showing improvement over time. Biomarkers of exposure and effect demonstrated changes associated with pesticide application and recovery after application ended. Deficits in NB performance were correlated with elevated pesticide exposure. Data demonstrated that repeated pesticide exposure may exert a long-term adverse impact on human health. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1528-7394
  • Document Type:
    Text
  • Funding:
    Cooperative Agreement
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    80
  • Issue:
    10
  • NIOSHTIC Number:
    nn:20055359
  • Citation:
    J Toxicol Environ Health A 2017 Jun; 80(10-12):542-555
  • Contact Point Address:
    Diane S. Rohlman, Occupational and Environmental Health, University of Iowa, 145 N. Riverside Drive, Iowa City, IA 52245, USA
  • Email:
    diane-rohlman@uiowa.edu
  • CAS Registry Number:
    Chlorpyrifos (CAS RN 2921-88-2)
  • Federal Fiscal Year:
    2017
  • NORA Priority Area:
    Agriculture, Forestry and Fishing
  • Performing Organization:
    University of Iowa, Iowa City
  • Peer Reviewed:
    True
  • Start Date:
    20010930
  • Source Full Name:
    Journal of Toxicology and Environmental Health, Part A: Current Issues
  • End Date:
    20270929
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:06eaa4b1e7828184a51c21f4f83620f94ef92f142fe86ec368a6fd99af5d583dabcb349e400efb577667b245af765b36a1aac936832a9e4ce3601a9aa2fd5669
  • Download URL:
  • File Type:
    Filetype[PDF - 1.65 MB ]
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