Longitudinal Assessment of Occupational Determinants of Chlorpyrifos Exposure in Adolescent Pesticide Workers in Egypt

Details

• Personal Author:
  Abdel-Rasoul G ; Bonner MR ; Callahan CL ; Hamad LA ; Hendy O ; Ismail AA ; Olson JR ; Rohlman DS
• Description:
  Chlorpyrifos (CPF) is an organophosphourus insecticide applied to cotton fields by adolescents employed by the Egyptian Ministry of Agriculture. Urinary 3,5,6-trichloro-2-pyridinol (TCPy) is a biomarker of CPF exposure that has substantial variability among these applicators. In order to identify predictors of CPF exposure, we conducted a longitudinal study of 43 adolescent pesticide applicators in Egypt from April 2010 to January 2011 in Egypt. Urinary TCPy was quantified at 25 time-points, prior to, during, and following application. We used log-linear regression and a best subset selection approach to identify the exposure determinants that were most predictive of cumulative TCPy and participants' highest TCPy values (peak exposure). Applicators had cumulative urinary TCPy levels ranging from 167 to 49,8208 ug/g creatinine. Total hours applying CPF (semi-partial r2 = 0.32), and total hours in the field applying other pesticides (semi-partial r2 = 0.08) were the strongest predictors of cumulative TCPy. Applicators had peak urinary TCPy levels ranging from 4 to 5715 ug/g creatinine. The amount of time applying pesticides prior to blood draw was the strongest predictor of peak TCPy (semi-partial r2 = 0.30). We also observed evidence that wearing clean clothes to work was associated with lower longitudinal TCPy. Our results suggest there is an opportunity for targeted interventions, particularly related to hygiene or implementation of personal protective equipment usage to reduce CPF exposure among adolescent pesticide workers. [Description provided by NIOSH]
• Subjects:
  Adolescent Biomarkers Occupational Exposure Occupational Health Personal Protective Equipment Safety
• Keywords:
  Adolescents Author Keywords: Organophosphates Biomonitoring Chlorpyrifos Exposure Assessment Occupational Exposure Organophosphorus Insecticides Personal Protective Equipment Pesticide Applicators PPE Work Clothing

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• ISSN:
  1438-4639
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; New York ; OSHA Region 2 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  220
• Issue:
  8
• NIOSHTIC Number:
  nn:20055358
• Citation:
  Int J Hyg Environ Health 2017 Nov; 220(8):1356-1362
• Contact Point Address:
  Catherine L. Callahan, 9609 Medical Center Drive Rockville, MD 20850, United States
• Email:
  Catherine.callahan@nih.gov
• CAS Registry Number:
  Chlorpyrifos (CAS RN 2921-88-2)
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Iowa, Iowa City
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  International Journal of Hygiene and Environmental Health
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:63953f9f3d70e53c9fea803f6346e0174d1672622369be37176f5401dccbaa761844154faec8f4ba3e1e9ec4533911bd2931933df150dd3a6d95313f288ba66b
• Download URL:
  https://stacks.cdc.gov/view/cdc/217686/cdc_217686_DS1.pdf
• File Type:
  [PDF - 560.55 KB ]