Second Hand Smoke, Age of Exposure and Lung Cancer Risk

Details

• Personal Author:
  Asomaning K ; Christiani, David C. ; Liu G ; Lynch TJ ; Miller DP ; Su L ; Wain JC
• Description:
  BACKGROUND: Exposure to second hand smoke (SHS) has been identified as a risk factor for lung cancer for three decades. It is also known that the lung continues to grow from birth to adulthood, when lung growth stops. We hypothesize that after adjusting for active cigarette smoking, if SHS exposure took place during the period of growth, i.e. in the earlier part of life (0-25 years of age) the risk of lung cancer is greater compared to an exposure occurring after age 25. METHOD: Second hand smoke exposure was self-reported for three different activities (leisure, work and at home) for this study population of 1669 cases and 1263 controls. We created variables that captured location of exposure and timing of first exposure with respect to a study participant's age (0-25, >25 years of age). Multiple logistic regressions were used to study the association between SHS exposure and lung cancer, adjusting for age, gender and active smoking variables. RESULT: For study participants that were exposed to SHS at both activities (work and leisure) and compared to one or no activity, the adjusted odds ratio (AOR) for lung cancer was 1.30 (1.08-1.57) when exposure occurred between birth and age 25 and 0.66 (0.21-1.57) if exposure occurred after age 25 years. Respective results for non-smokers were 1.29 (0.82-2.02) and 0.87 (0.22-3.38), and current and ex-smokers combined 1.28 (1.04-1.58) and 0.66 (0.15-2.85). CONCLUSION: All individuals exposed to SHS have a higher risk of lung cancer. Furthermore, this study suggests that subjects first exposed before age 25 have a higher lung cancer risk compared to those for whom first exposure occurred after age 25 years. [Description provided by NIOSH]
• Subjects:
  Adolescent Aging Environmental Exposure Lung Lung Diseases Men Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers Tobacco Products Women

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• Keywords:
  Active Smoking Adolescents Age Groups Age Of Exposure Author Keywords: Second Hand Smoke Cancer Case Control Study Children Cigarette Smoking Exposure Levels Humans Lung Cancer Lung Cancer Risk Lung Growth Risk Factors Secondhand Smoke Smoking Statistical Analysis

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• ISSN:
  0169-5002
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  13-20
• Volume:
  61
• Issue:
  1
• NIOSHTIC Number:
  nn:20054358
• Citation:
  Lung Cancer 2008 Jul; 61(1):13-20
• Contact Point Address:
  David C. Christiani, Department of Environmental Heath (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, MA 02115
• Email:
  dchris@hsph.harvard.edu
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Lung Cancer
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ca32148f589f781908453c8779c15514b3b0f2f45e8f17b7f3930bc168265341f3146fe7c8f73a02783b1bb1c0014b64264f690b9ac3324dbe4ab0f11aa2eefa
• Download URL:
  https://stacks.cdc.gov/view/cdc/216943/cdc_216943_DS1.pdf
• File Type:
  [PDF - 145.00 KB ]