Second Hand Smoke Exposure and Survival in Early-Stage Non-Small-Cell Lung Cancer Patients

Details

• Personal Author:
  Asomaning K ; Christiani, David C. ; Heist RS ; Liu G ; Lynch TJ ; Miller DP ; Neuberg DS ; Wain JC ; Zhou W
• Description:
  Purpose: Second hand smoke (SHS) exposure is associated with higher risk of lung cancer. However, the role of SHS in lung cancer survival is not clear. Experimental design: We examined the association between self-reported SHS exposure before diagnosis and overall survival and recurrence-free survival in 393 early-stage non-small-cell lung cancer patients. SHS exposure was analyzed by both duration and location of exposure using log-rank test and Cox proportional hazard models, adjusting for covariates including pack-years of smoking. Results: The median follow-up time was 66 months (range, 0.2-140 months). There were 135 recurrences and 213 deaths. The 5-year overall survival rates were 71% [95% confidence interval (95% CI), 62-81%], 61% (51-72%), 49% (38-60%), and 47% (37-58%), respectively, for patients with the lowest to highest quartile of SHS exposure durations (P < 0.001, log-rank test), with the adjusted hazard ratio (AHR) of 1.57 (95% CI, 1.02-2.41) for the highest versus lowest quartile of SHS exposure durations (P(trend) = 0.04). For different SHS exposure locations, a stronger association was found for SHS exposure at work (AHR of the highest versus lowest quartile, 1.71; 95% CI, 1.12-2.61; P(trend) = 0.03) than for exposure at home (AHR, 1.26; 95% CI, 0.86-1.86; P(trend) = 0.20) or leisure places (AHR, 1.28; 95% CI, 0.83-1.95; P(trend) = 0.16). Similar associations were observed when SHS exposure durations were dichotomized into two or three groups and between SHS exposure and recurrence-free survival. Conclusions: SHS exposure is associated with worse survival in early-stage non-small-cell lung cancer patients, especially for SHS exposure at the work. [Description provided by NIOSH]
• Subjects:
  Aging Environmental Exposure Lung Lung Diseases Men Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers Women

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• Keywords:
  Age Groups Cancer Carcinomas Exposure Levels Hazards Health Effects Humans Lung Cancer Models Risk Factors Secondhand Smoke Smoking Statistical Analysis

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• ISSN:
  1078-0432
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• Issue:
  23
• NIOSHTIC Number:
  nn:20060029
• Citation:
  Clin Cancer Res 2006 Dec; 12(23):7187-7193
• Contact Point Address:
  Wei Zhou, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
• Email:
  wzhou@hsph.harvard.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Clinical Cancer Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9f211fb9a7e59ee269aa14d86e6e6fee14b27718dd8cf7f036a77ecb0a19d265d131f92614e1c29f7971e94481d8a84daf8b001fa97109b890aab855c87707e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/224066/cdc_224066_DS1.pdf
• File Type:
  [PDF - 281.63 KB ]